Evolution of the Liquid Biopsy in Metastatic Prostate Cancer

We reviewed the literature for the biologic, prognostic, and predictive significance of circulating prostate cancer tumor cells (CTCs), and circulating tumor DNA (ctDNA) in the blood of metastatic castration resistant prostate cancer patients (mCRPC). CTCs demonstrate robust prognostic value independent of PSA in predicting overall survival. The CTC androgen receptor variant receptor 7 (AR-V7) phenotype predicts resistance to androgen receptor synthesis inhibitors and sensitivity to taxane based chemotherapy in mCRPC patients who are candidates for second line therapy.

Source: Urology - June 13, 2019 Category: Urology & Nephrology Authors: Jose G. Moreno, Leonard G. Gomella Source Type: research