Prevalence and comorbidity of autism spectrum disorder in Spain: study protocol for a systematic review and meta-analysis of observational studies

The objective of this study will be to systematically evaluate published and unpublished observational studies that present prevalence and comorbidity of ASD among children, adolescent and adult population in Spain.Methods/designWe designed and registered a study protocol for a systematic review and meta-analysis of descriptive epidemiology data. Observational studies (cohort, cross-sectional) reporting the prevalence of ASD and conducted in a wide range of people (e.g. general population, outpatient and/or school settings) will be included. The primary outcome will be the prevalence of ASD. Secondary outcomes will be the prevalence of any physical or mental comorbidity in association with ASD. No limitations will be imposed on publication status, study conduct period, and language of dissemination. Comprehensive literature searches will be conducted in seven electronic databases (from January 1980 onwards), including PubMed/MEDLINE, EMBASE, Scopus, Web of Science, PsycINFO, IME —Spanish Medical Index and IBECS—Spanish Bibliographic Index of Health Sciences. Grey literature will be identified through searching dissertation databases, Google Scholar and conference abstracts. Two team members will independently screen all citations, full-text articles, and abstract data. Potential conflicts will be resolved through discussion. The study methodological quality (or bias) will be appraised using an appropriate tool. If feasible, we will conduct random effects meta-anal...
Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research

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(Skolkovo Institute of Science and Technology (Skoltech)) Skoltech scientists looked into the differences in the concentrations of multiple metabolites in healthy humans and individuals suffering from Autism Spectrum Disorder (ASD), gaining a deeper insight into the molecular processes that take place in the brain of autistic individuals. The results of the study were published in Nature's ?ommunications Biology journal.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
(Anglia Ruskin University) New research indicates that transgender and non-binary individuals are significantly more likely to have autism or display autistic traits than the wider population -- a finding that has important implications for gender confirmation treatments.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Embryonic exposure to valproic acid (VPA) is known to produce sociability deficits, resembling human autistic phenotypes, in several vertebrate species. Animals living in groups prefer the proximity of peers and have the ability to perceive and to respond to social signals for modifying behavior. Chicks of Galliform birds, known to display early preference behaviors, have been used extensively for adaptive learning studies. Young precocial birds seem to be useful models also for studying the effect of embryonic VPA treatment. Here, domestic chicken eggs were injected with sodium valproate (200 µl of 35 µmol/l s...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
AbstractSocial narratives, or story-based interventions, are defined as stories that describe social situations, appropriate social behaviors to display, and when to display the specified behaviors. Social narratives are a commonly implemented and empirically evaluated procedure used to improve social behavior and decrease the probability of aberrant behavior for individuals diagnosed with autism spectrum disorder. Although social narratives are a commonly implemented and evaluated procedure, recommendations about their use and effectiveness is conflicting. This paper reviews six interventions that fit the definition of so...
Source: Journal of Developmental and Physical Disabilities - Category: Disability Source Type: research
AbstractBackgroundThe 1.6 Mb 3q29 deletion is associated with neurodevelopmental and psychiatric phenotypes, including increased risk for autism spectrum disorder (ASD) and a 20 to 40-fold increased risk for schizophrenia. However, the phenotypic spectrum of the deletion, particularly with respect to ASD, remains poorly described.MethodsWe ascertained individuals with 3q29 deletion syndrome (3q29Del, “cases,”n = 93, 58.1% male) and typically developing controls (n = 64, 51.6% male) through the 3q29 registry ( Self-report of neuropsychiatric...
Source: Molecular Autism - Category: Molecular Biology Source Type: research
Parents and caregivers often notice the signs of autism, or autism spectrum disorder, when a child is still very young. Learn about the possible signs of autism in a 3-year-old here.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Autism Source Type: news
This study examined behavioural, adaptive and cognitive data provi...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
DiscussionWe prepared a well-designed clinical trial to investigate the safety and effectiveness of UGSJB on ASD symptoms compared with placebo treatment. The results from this study will provide clinical evidence on the safety, effectiveness, and economic value of UGSJB combined with acupuncture in children with ASD.Trial registrationClinical Research Information Service:KCT0003007 (registered on April 5, 2018)
Source: Trials - Category: Research Source Type: clinical trials
ConclusionsNotable overlap in eating difficulties, behavioural problems and sensory profiles of children with ARFID, ASD or PE, with more severe aberrations in ARFID (food-responsiveness) and ASD (hypersensitivity and social problems) on specific dimensions, argue for a dimensional approach to improve therapy and management of children with these disorders.
Source: European Psychiatry - Category: Psychiatry Source Type: research
Anarticle published recently by the American Lung Association claims that vaping causes popcorn lung and COPD. There is no evidence to support either of these assertions. In fact, I'm not aware of a single case of either popcorn lung or COPD that has ever been diagnosed in a vaper without a history of cigarette smoking. Even active smoking itself is not associated with popcorn lung, and cigarette smoke contains about 750 times the amount of diacetyl (the putative cause of popcorn lung) than e-cigarette aerosol. So the American Lung Association is lying about the health risks of vaping.The Rest of the StoryHowever, that's n...
Source: The Rest of the Story: Tobacco News Analysis and Commentary - Category: Addiction Source Type: blogs
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