Medline Announces First Infection Control Product EPA-registered to Kill Emerging Pathogen

Micro-Kill Bleach Germicidal Bleach Wipes shown to kill Candida auris First EPA approved product on market* available to hospitals and clinics fighting multidrug resistant fungus NORTHFIELD, Ill., June 14, 2019 -- (Healthcare Sales &Marketing Networ... Devices, FDA, Product Launch, Distribution Medline, Micro-Kill Bleach
Source: HSMN NewsFeed - Category: Pharmaceuticals Source Type: news

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Publication date: Available online 18 June 2019Source: Journal of Hospital InfectionAuthor(s): B. Short, J. Brown, C. Delaney, L. Sherry, C. Williams, G. Ramage, R. KeanSummarySurfaces within healthcare play a key role in the transmission of drug-resistant pathogens. Candida auris is an emerging multidrug-resistant yeast which can survive for prolonged periods on environmental surfaces. Here we show that the ability to form cellular aggregates increases survival after 14 days, which coincides with the upregulation of biofilm-associated genes. Additionally, the aggregating strain demonstrated tolerance to clinical concentra...
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
Publication date: Available online 26 June 2019Source: Process BiochemistryAuthor(s): Sujatha Peela, Veeranki Girijashankar, Sunil Prasad Dhanunjay Ponamgi, Nagavalli Mandali, Ganji Purnachandra NagarajAbstractA new tetracycline analogue SBR-22 was isolated using bioactivity guided screening of the Streptomyces psammoticus 125-vr, from sea residues of the Visakhapatnam coast of South India. Based on spectral data, the name and structure of the antibiotic SBR-22 were identified as 1,5-dihydroxy- 5-methyl- 7- (N,N-dimethyl) amino- 6,8,11,12- tetraoxo- 7,9,10 –hexahydro- naphthacene. Unlike the standard oxytetracycline ...
Source: Process Biochemistry - Category: Biochemistry Source Type: research
Candida auris is an emerging multidrug-resistant fungal pathogen that has been associated with nosocomial bloodstream and deep wound infections causing a high mortality rate mainly in intensive care unit (ICU) patients. Laboratories currently rely on phenotypic testing using commercial automated systems for identification of yeasts; however, this technique has often led to misidentification of C. auris to other closely related species. We developed and validated a TaqMan-based real-time PCR assay on the BD Max platform targeting ribosomal DNA (rDNA) region nucleotide sequences to quickly and accurately test for C. auris in...
Source: Journal of Clinical Microbiology - Category: Microbiology Authors: Tags: Mycology Source Type: research
Source: Journal of Occupational and Environmental Hygiene - Category: Occupational Health Authors: Source Type: research
(Beth Israel Deaconess Medical Center) Microbiologists at Beth Israel Deaconess Medical Center have shown that a combination of anti-fungal and anti-bacterial medications may be an effective weapon against the recently discovered multidrug resistant, Candida auris (C. auris).
Source: EurekAlert! - Biology - Category: Biology Source Type: news
Abstract Candida auris is an emerging species of yeast characterized by colonization of skin, persistence in the healthcare environment, and antifungal resistance. C. auris was first described in 2009 from a single isolate but has since been reported in more than 25 countries worldwide. Resistance to fluconazole and amphotericin B is common, and resistance to the echinocandins is emerging in some countries. Antifungal resistance has been shown to be acquired rather than intrinsic and the primary mechanisms of resistance to the echinocandins and azoles have been determined. There are a number of new antifungal agen...
Source: Fungal Genetics and Biology - Category: Biology Authors: Tags: Fungal Genet Biol Source Type: research
Publication date: Available online 11 June 2019Source: Journal of Global Antimicrobial ResistanceAuthor(s): Malini R Capoor, Chinari P Subudhi, Andrew Collier, Abhijit M BalAbstractAntimicrobial resistance is a global threat. To counter the growing menace of antibiotic resistance, several stewardship initiatives have been incorporated a part of overarching strategy of healthcare delivery. In comparison, antifungal stewardship has attracted limited attention due to several factors such as limited antifungal resistance and less burden of fungal infections compared to bacterial infections. However, emergence of resistant fung...
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
We describe the synthesis of epi-oligomycin A, a (33S)-diastereomer of the antibiotic oligomycin A. The structure of (33S)-oligomycin A was determined by elemental analysis, spectroscopic studies, including 1D and 2D NMR spectroscopy, and mass spectrometry. Isomerization of C33 hydroxyl group led to minor changes in the potency against Aspergillus niger, Candida spp., and filamentous fungi whereas the activity against Streptomyces fradiae decreased by approximately 20-fold compared to oligomycin A. We observed that 33-epi-oligomycin A had the same activity on the human leukemia cell line K562 as oligomycin A but was more p...
Source: Natural Product Research - Category: Biochemistry Authors: Tags: Nat Prod Res Source Type: research
In this study, the antibiofilm activities of twelve flavonoids were initially investigated. Three most active flavonoids, namely, fisetin, phloretin, and curcumin, dose-dependently inhibited biofilm formation by a reference A. baumannii strain and by several clinical isolates, including four multidrug-resistant isolates. Furthermore, the antibiofilm activity of curcumin (the most active flavonoid) was greater than that of the well-known biofilm inhibitor gallium nitrate. Curcumin inhibited pellicle formation by and the surface motility of A. baumannii. Interestingly, curcumin also showed antibiofilm activity against Candid...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Jin-Yan Wu1,2, Duan-Yong Zhou2, Ying Zhang2, Fei Mi3 and Jianping Xu1,2,4* 1Public Research Laboratory, Hainan Medical University, Haikou, China 2Laboratory for Conservation and Utilization of Bio-Resources and Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming, China 3Research Institute of Nutrition and Food Science, Kunming Medical University, Kunming, China 4Department of Biology, McMaster University, Hamilton, ON, Canada Candida tropicalis is a globally distributed human pathogenic yeast, especially prevalent in tropical and sub-tropical regions. Over the last s...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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