Doctors could use SCORPION venom to fight human infections including tuberculosis

Scientists led by Stanford University discovered two compounds in the venom which hold promise. However the hard-to-extract venom would cost millions of pounds to produce for medicine.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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[WHO] Abuja, 13 August 2019 - "I have been injecting drugs for a long time and we share syringes," says Ali who lives in the suburb of the Federal Capital Territory (FCT) and recently diagnosed to be co-infected with Tuberculosis (TB) and HIV. Consequent to difficulties of life in the streets, Ali was exposed to drug use as early as age 10 and started using injectable drugs when he was 14. "I wish I can stop now though, but It is very difficult" he laments.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
ConclusionSerotonin syndrome should be considered in patients on multiple serotonergic agents on the background of end ‐stage renal disease. Prompt recognition and distinction from lupus activity can significantly impact management decisions.
Source: International Journal of Rheumatic Diseases - Category: Rheumatology Authors: Tags: APLAR GRAND ROUND CASE Source Type: research
AbstractPopulation attributable fraction (PAF) refers to the proportion of all cases with a particular outcome in a population that could be prevented by eliminating a specific exposure. The authors of a recent paper evaluated the prevalence and estimated the PAFs for risk factors of TB among elderly people in China [Inf Dis Poverty. 2019;8:7]. Confounding is inevitable in observational studies and Levin ’s formula is of limited use in practice for unbiasedly estimating PAF. In a complex survey design, an unbiased estimation of the PAF can be calculated using a sample-weighted version of the Miettinen formula or a sa...
Source: Infectious Diseases of Poverty - Category: Infectious Diseases Source Type: research
Nature, Published online: 19 August 2019; doi:10.1038/d41586-019-02482-yAlkaline compound helps the tuberculosis bacterium to ward off an acid attack from host cells.
Source: Nature AOP - Category: Research Source Type: research
Publication date: Available online 16 August 2019Source: The Lancet Respiratory MedicineAuthor(s): Hanif Esmail, Marc C Lipman, Andrew Nunn, Timothy M Walker
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
ConclusionsTaken together, our results demonstrated that PAS resistance and mutations in katG, inhA promoter or oxyR-ahpC intergenic region in INH resistant M. tuberculosis has little effect on pasiniazid susceptibility.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
This article describes the simultaneous determination of bedaquiline fumarate (TMC-207) and rifabutin in human plasma by stable isotope dilution tandem mass spectrometry. The methodology was developed for an investigation of potential drug-drug interactions of the two anti-tuberculosis drugs when given together to healthy human volunteers. Use of the two drugs in combination to treat disease caused by Mycobacterium tuberculosis is contemplated as the bacterium becomes resistant to many currently available drugs.
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research
aacute;n Vančo Zdeněk Trávníček Alois Čížek Andrzej Bąk Josef Jampílek A series of twenty-six methoxylated and methylated N-aryl-1-hydroxynaphthalene- 2-carboxanilides was prepared and characterized as potential anti-invasive agents. The molecular structure of N-(2,5-dimethylphenyl)-1-hydroxynaphthalene-2-carboxamide as a model compound was determined by single-crystal X-ray diffraction. All the analysed compounds were tested against the reference strain Staphylococcus aureus and three clinical isolates of methicillin-resistant S. aureus as well as against Mycobacterium tubercu...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
In this study, Mycobacterium avium (n= 77, 17.7%), Mycobacterium intracellulare (n= 70, 16.1%), Mycobacterium szulgai (n= 19, 4.4%), Mycobacterium kansasii (n= 10, 2.3%) ve Mycobacterium smiae (n= 9, 2.1%) were isolated as slowly growing mycobacteria from the pulmonary patients. Susceptibility testing was performed in cation-adjusted Mueller-Hinton broth (CAMH), supplemented with "oleic acid, albumin dextrose catalase" according to CLSI/ M24-A2 guideline recommendations. For the antibiotic susceptibility test, ready-to-use plaque drugs for slow-growing mycobacteria (SLOMYCO-Sensititre, TREK Diagnostic Systems Ltd...
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
Authors: Bozok T, Kayar B, Yakıcı G, Eker E, Marzi M, Karslı F, Köksal F Abstract Tuberculosis (TB) is a chronic, granulomatous and necrotizing disease caused by microorganisms belonging to the Mycobacterium tuberculosis complex group. In 2017, 6.4 million new TB cases have been reported according to the World Health Organization 2018 Global Tuberculosis Report. TB remains among the major health problems of our time due to the increasing drug resistance problem and the difficulties in definitive diagnosis in recent years. It is stated by clinicians that intensive use of quinolone group drugs with oral form ...
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
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