Local and Systemic IL-7 Concentration in Gastrointestinal-Tract Cancers.
Conclusions: IL-7 protein is overexpressed in EC, GC, and CRC, but concentrations differ both in tumor and tumor-adjacent tissue with respect to tumor location. More advanced cancers have lower IL-7 concentrations in the immediate environment of the tumor. At the systemic level, IL-7 is elevated in CRC and EC, but not CC or GC. IL-7 dependence on the location of the primary tumor should be taken into account in future IL-7-based immunotherapies. Functional studies explaining a role of IL-7 in gastrointestinal cancers are needed.
PMID: 31185636 [PubMed - in process]
Source: Medicina (Kaunas) - Category: Universities & Medical Training Authors: Bednarz-Misa I, Diakowska D, Krzystek-Korpacka M Tags: Medicina (Kaunas) Source Type: research