Non paraneoplastic immune-mediated calcium channel chorea.

We present a case of chorea in association with an isolated serum elevation in N-type calcium channel antibodies and clinical improvement with intravenous immunoglobulin. PMID: 31191155 [PubMed]
Source: Baylor University Medical Center Proceedings - Category: Universities & Medical Training Authors: Tags: Proc (Bayl Univ Med Cent) Source Type: research

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Nitish Agarwal, Shashank S Kale, Kalpana KumariNeurology India 2019 67(5):1334-1340 Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome of certain mesenchymal tumors which secrete fibroblast growth factor-23 (FGF-23) responsible for causing features of hypophosphatemia and osteomalacia in these patients. Most of them involve the appendicular skeleton and occasionally the craniofacial regions. Involvement of spine is exceedingly rare. Through this paper, the authors present a rare case of a 71-year-old male with TIO due to a lesion in the cervical spine (right C2 lamina) which was proven to be a phosphaturic...
Source: Neurology India - Category: Neurology Authors: Source Type: research
Stiff person syndrome (SPS) is a disorder characterized by fluctuating, progressive and painful spasms of the limbs, trunk and face. The condition is frequently associated with other diseases, including malignancies1. Up to 10% of SPS cases are paraneoplastic (PSPS) and occur with various types of cancer 2. SPS is thought to be immune-mediated, with up to 60% of patients demonstrating antibodies to glutamic acid decarboxylase (GAD), the rate-limiting enzyme for the production of the inhibitory neurotransmitter γ-aminobutyric acid (GABA).
Source: Journal of Pain and Symptom Management - Category: Palliative Care Authors: Source Type: research
AbstractImmune response against neuronal and glial cell surface and cytosolic antigens is an important cause of encephalitis. It may be triggered by activation of the immune system in response to an infection (para-infectious), cancer (paraneoplastic), or due to a patient ’s tendency toward autoimmunity. Antibodies directed toward neuronal cell surface antigens are directly pathogenic, whereas antibodies with intracellular targets may become pathogenic if the antigen is transiently exposed to the cell surface or via activation of cytotoxic T cells. Immune-mediated encephalitis is well recognized and may require inten...
Source: Neurocritical Care - Category: Neurology Source Type: research
Publication date: Available online 13 November 2019Source: Autoimmunity ReviewsAuthor(s): Guojun Geng, Xiuyi Yu, Jie Jiang, Xinhua YuAbstractParaneoplastic autoimmune disorders (PAD) represent a group of autoimmune diseases associated with neoplasms. As a consequence of a remote autoimmunity-mediated effect, PAD are found in multiple organs or tissues, including the skin, blood and nervous system. Compared with non-paraneoplastic autoimmune diseases, PAD have different aetiologies, pathologies, disease symptoms and treatment responses. There are two main origins of autoimmunity in PAD: neoplasm-mediated dysregulated homeos...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Authors: Conticini E, Dardani L, Crescentini F, Salvarani C PMID: 31694756 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Gangliosides are sialylated glycosphingolipids, highly abundant in our nervous system. Antibodies targeting gangliosides are usually developed as a consequence of molecular mimicry following infections. Antiganglioside antibodies are implicated in many neurological disorders such as acute and chronic polyradiculoneuropathies which includes different variants of Guillain-Barr é syndrome, chronic inflammatory demyelinating polyradiculoneuropathy and multifocal motor neuropathy. Presence of such antibodies in paraneoplastic peripheral neuropathy, neurodegenerative disorders, multiple sclerosis, myasthenia gravis and am...
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Review Article Source Type: research
ConclusionCase reports on paraneoplastic syndrome associated with cancer increases the knowledge on this topic, especially on rare presentations. Our findings further support that early diagnosis of various paraneoplastic symptoms is critical for patient´s treatment and prognosis.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
We describe a 77-year-old man with a sudden onset of dizziness, vomiting, and gait disturbances. Following imaging studies, a diagnosis of bulbar ischemic stroke with left vertebral artery stenosis was made. Based on a history of polymyalgia rheumatica, on laboratory tests, and brain digital subtraction angiography, a diagnosis of GCA was advanced and the patient underwent high-dose steroidal therapy. After a total body 18-FGD PET imaging, a pulmonary adenocarcinoma was found.Vertebral artery involvement is a rare but important occurrence in GCA as it carries a high mortality rate, and may require a vigorous therapeutic ap...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Purpose of review Status epilepticus is a neurological emergency associated with high morbidity and mortality. There is a lack of robust data to guide the management of this neurological emergency beyond the initial treatment. This review examines recent literature on treatment considerations including the choice of continuous anesthetics or adjunctive anticonvulsant, the cause of the status epilepticus, and use of nonpharmacologic therapies. Recent findings Status epilepticus remains undertreated and mortality persists to be unchanged over the past 30 years. New anticonvulsant choices, such as levetiracetam and lacos...
Source: Current Opinion in Critical Care - Category: Nursing Tags: CARDIOPULMONARY RESUSCITATION AND OTHER EMERGENCIES: Edited by Marek A. Mirski Source Type: research
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