Lipoprotein (a) level is associated with plaque vulnerability in patients with coronary artery disease: An optical coherence tomography study

Publication date: September 2019Source: IJC Heart &Vasculature, Volume 24Author(s): Yusuke Muramatsu, Yoshiyasu Minami, Ayami Kato, Aritomo Katsura, Toshimitsu Sato, Ryota Kakizaki, Teruyoshi Nemoto, Takuya Hashimoto, Kazuhiro Fujiyoshi, Kentaro Meguro, Takao Shimohama, Junya AkoAbstractBackgroundHigh lipoprotein (a) [Lp(a)] levels are an independent factor for worse prognosis in patients with coronary artery disease (CAD). However, the association between serum Lp(a) level and coronary plaque vulnerability remains to be determined.MethodsA total of 255 consecutive patients with CAD who underwent optical coherence tomography imaging of culprit lesions were included. Patients were divided into 2 groups according to their Lp(a) levels (the higher Lp(a) group [≥25 mg/dL], n = 87; or the lower Lp(a) group [
Source: IJC Heart and Vasculature - Category: Cardiology Source Type: research

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CONCLUSION: ATV inhibited ROS generation and activated IL-1 β/IL-6 secretion in PBMNC of diabetes patients. Its effect was not affected by the hyperglymemia. PMID: 31416412 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
Publication date: Available online 16 August 2019Source: Journal of Sport and Health ScienceAuthor(s): Carlos Cristi-Montero, Javier Courel-Ibáñez, Francisco B Ortega, Jose Castro-Piñero, Alba Santaliestra Pasias, Angela Polito, Jérémy Vanhelst, Ascensión Marcos, Luis M Moreno, Jonatan R Ruiz, HELENA study groupAbstractPurposeTo analyze the mediation role of cardiorespiratory fitness (CRF) on the association between fatness and cardiometabolic risk (CMRs) in European adolescents.MethodsA cross-sectional study was conducted in adolescents (n = 525; boys 46%; 14.1 ± 1.1 ye...
Source: Journal of Sport and Health Science - Category: Sports Medicine Source Type: research
Evaluating the Lipid-Lowering Effects of α-lipoic Acid Supplementation: A Systematic Review. J Diet Suppl. 2019 Aug 15;:1-15 Authors: Erickson N, Zafron M, Harding SV, Marinangeli CPF, Rideout TC Abstract Dietary supplementation of α-lipoic acid, an 8-carbon organosulfur compound, has been widely reported to lower blood glucose concentration and/or improve insulin sensitivity in previous randomized controlled trials. Although animal model studies further report fairly consistent lipid lowering in both blood and tissue pools in response to α-lipoic acid supplementation, results from hu...
Source: Journal of Dietary Supplements - Category: Nutrition Tags: J Diet Suppl Source Type: research
A 76-year-old reader who weighs only nine stone and walks at least a mile a day has asked DR ELLIE CANNON why she has high cholesterol and whether it may be genetic.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Publication date: Available online 16 August 2019Source: Reproductive ToxicologyAuthor(s): Debbie Yancu, Thomas SandersonAbstractWe determined whether 5 common essential oils (basil, fennel seed, orange, black pepper and sage) interfered with feto-placental steroidogenesis in a co-culture model composed of fetal-like adrenocortical (H295R) and placental trophoblast-like (BeWo) cells. After a 24 h exposure, only basil and fennel seed oil significantly increased hormone concentrations of estradiol, estrone, dehydroepiandrosterone (DHEA), androstenedione, progesterone, and estriol. Basil and fennel seed oil were shown ...
Source: Reproductive Toxicology - Category: Toxicology Source Type: research
CONCLUSION: In peritoneal dialysis patients, spironolactone did not attenuate the progression of CC. However, large-scale studies are needed to confirm this observation. Disorders of mineral metabolism and dyslipidemia are involved in the progression of CC. PMID: 31419271 [PubMed - as supplied by publisher]
Source: Jornal Brasileiro de Nefrologia - Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research
Abstract Non-Alcoholic Fatty Liver Disease (NAFLD), the most common liver disease, is characterized by accumulation of fat (>5% of the liver tissue), in the absence of alcohol abuse or other chronic liver diseases. Its prevalence is increasing because of obesity, metabolic syndrome or Type 2 Diabetes Mellitus (T2DM). NAFLD can cause liver inflammation and progress to Non-Alcoholic Steatohepatitis (NASH), fibrosis, cirrhosis or Hepatocellular Cancer (HCC). Nevertheless, Cardiovascular Disease (CVD) is the most common cause of morbidity and mortality in NAFLD/NASH patients. Current guidelines suggest the use of p...
Source: Current Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Vasc Pharmacol Source Type: research
The food contains a healthy fibre that reduces the risk of heart disease and stroke. → Support PsyBlog for just $4 per month. Enables access to articles marked (M) and removes ads. → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Cholesterol Source Type: blogs
We examined T1w/T2w ratio maps in 515 cognitively healthy middle-aged participants from the ALFA study (ALzheimer and FAmilies) cohort, a single-site population-based study enriched for AD risk (68 APOE-ε4 homozygotes, 197 heterozygotes, and 250 non-carriers). Using tract-based spatial statistics, we assessed the impact of age and APOE genotype on this ratio taken as an indirect descriptor of myelin content.Healthy APOE-ε4 carriers display decreased T1w/T2w ratios in extensive regions in a dose-dependent manner. These differences were found to interact with age, suggesting faster changes in individuals with...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
SUPPLEMENTS can be taken for a variety of health ailments. For people with high cholesterol, symptoms may not be obvious but can increase a person ’s risk of more serious health problems. A healthy diet can help prevent the condition, however, certain supplements may also be taken to help lower cholesterol.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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