The bone metastasis niche in breast cancer-potential overlap with the haematopoietic stem cell niche in vivo

Conclusion: Our data provide evidence that homing of breast cancer cells is independent of their ER status and that the breast cancer bone metastasis niche is located within the trabecular region of bone, an area rich in osteoblasts and microvessels. The increased number of breast cancer cells homing to bone after mobilisation of HSCs suggests that the HSC and the bone metastasis niche overlap.
Source: Journal of Bone Oncology - Category: Cancer & Oncology Source Type: research