Connexin43 in Neonatal Excitatory Neurons is Important for Short-Term Motor Learning.

Connexin43 in Neonatal Excitatory Neurons is Important for Short-Term Motor Learning. Brain Res. 2019 Jun 10;: Authors: Wang M, Chen JJ, Huang Q, Su X, Yu YC, Liu LY Abstract In the neocortex, gap junctions are expressed at very early developmental stages, and they are involved in many processes such as neurogenesis, neuronal migration and synapse formation. Connexin43 (Cx43), a gap junction protein, has been found to be abundantly expressed in radial glial cells, excitatory neurons and astrocytes. Although accumulating evidence suggests that Cx43-mediated gap-junctional coupling between astrocytes plays an important role in the central nervous system, the function of Cx43 in early excitatory neurons remains elusive. To investigate the impact of Cx43 deficiency in excitatory neurons at early postnatal stages, we conditionally knocked out Cx43 in excitatory neurons under the Emx1 promoter by tamoxifen induction. We found that deletion of Cx43 around birth did not impair the laminar distribution of excitatory neurons in the neocortex. Moreover, mice with Cx43 deletion during the early postnatal stages had normal anxiety-like behaviors, depression-related behaviors, learning and memory-associated behaviors at adolescent stages. However, Cx43 conditional knockout mice exhibited impaired motor-learning behavior. These results suggested that Cx43 expression in excitatory neurons at early postnatal stages contributes to short-term motor learning capacity. ...
Source: Brain Research - Category: Neurology Authors: Tags: Brain Res Source Type: research

Related Links:

CONCLUSIONS: Disorders of mother infant bonding are seen in healthy postpartum mothers. The frequency of mild disorders of bonding appears to be similar across countries and this condition warrants further attention. PMID: 31326768 [PubMed - as supplied by publisher]
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
.
Source: Journal of Maternal-Fetal and Neonatal Medicine - Category: Perinatology & Neonatology Authors: Source Type: research
About 15 % of mothers suffer from postpartum psychiatric disorders such as depression, anxiety, or psychosis. Numerous studies have shown maternal caregiving behavior to be negatively affected under these circumstances. The current study sets out to shed light on specific caregiving behaviors of affected mothers in the context of parental mental illness at an early stage. There are several methods to assess maternal caregiving behavior in terms of sensitivity. However, all of them have limitations regarding the peculiarities of mothers with postpartum disorders, i.e. changes in affect regulation, and the early onset of t...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Maternal prenatal depressive or anxiety symptoms are associated with adverse maternal and infant health outcomes. With prevalence rates of maternal prenatal depression and anxiety ranging between 10 and 20%, a...
Source: Trials - Category: General Medicine Authors: Tags: Study protocol Source Type: research
Conditions:   Pregnancy Related;   Stress, Psychological;   Anxiety;   Perinatal Depression Interventions:   Behavioral: SMART Pregnancy;   Behavioral: Treatment as usual Sponsors:   Stony Brook University;   Massachusetts General Hospital;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractPrenatal maternal depression is associated with developmental disorders in offspring. However, the specific effects of the intensity of prenatal depressive symptoms on infant behavior remain poorly explored. The aim of this work is to explore the links between early neonatal behavior and maternal prenatal depressive symptoms, independently from maternal pre- and postnatal anxiety and early postnatal maternal depressive symptoms. Five hundred and ninety-eight women and their newborns from the MATQUID cohort were prospectively evaluated during the 8th month of pregnancy (T1) and at day 3 postpartum (T2). We analyzed ...
Source: European Child and Adolescent Psychiatry - Category: Psychiatry Source Type: research
Conditions:   Depression, Postpartum;   Anxiety Intervention:   Behavioral: Therapist-assisted ICBT Sponsor:   University of Regina Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
More News: Anxiety | Brain | Depression | Learning | Neurology | Perinatology & Neonatology | Postnatal Depression | Tamoxifen | Universities & Medical Training