Peripheral Anti-inflammatory Cytokine Interleukin-10 Treatment Mitigates Interleukin-1 β - Induced Anxiety And Sickness Behaviors in Adult Male Rats.

Peripheral Anti-inflammatory Cytokine Interleukin-10 Treatment Mitigates Interleukin-1β - Induced Anxiety And Sickness Behaviors in Adult Male Rats. Behav Brain Res. 2019 Jun 10;:112024 Authors: Munshi S, Parrilli V, Rosenkranz JA Abstract Pro-inflammatory cytokines produce manifestations of sickness during inflammation, such as malaise and lethargy. They also contribute to effects of inflammation on mood. Anti-inflammatory cytokines counteract damage caused by inflammatory processes and can limit the severity of inflammation. However, very little is known about the role of anti-inflammatory cytokines in sickness and mood changes during immune activation. The purpose of this study was to determine if a prototypical anti-inflammatory cytokine, interleukin 10 (IL-10), can offset sickness behavior and anxiety caused by a pro-inflammatory cytokine, and whether IL-10 itself modifies anxiety. Rodent models of sickness display suppression of behavioral activity that may reflect lethargy or malaise, while models of anxiety display reduced exploration in several tasks. The effects of peripheral single dose of cytokines on open field exploration, social interaction and elevated plus maze (EPM) tests in adult male Sprague-Dawley rats were measured at 30 - 50 min post-treatment. The prototypical pro-inflammatory cytokine IL-1β (1 μg, i.p.) caused a decrease in locomotor activity indicative of sickness behavior, but disproportionately reduc...
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research

Related Links:

More than 60 percent of CBD users were taking it for anxiety, according to a survey of 5,000 people. Does it help?
Source: NYT Health - Category: Consumer Health News Authors: Tags: Cannabis Foods and Products Anxiety and Stress Marijuana Mental Health and Disorders Drugs (Pharmaceuticals) Post-Traumatic Stress Disorder Sleep Addiction (Psychology) Research Clinical Trials Insomnia Depression (Mental) Hemp Source Type: news
CONCLUSIONS: For most mental disorders, refugees were less likely to be admitted to hospital for suicide attempt or die by suicide compared with Swedish-born individuals. Further research on risk and protective factors for suicide attempt and suicide among refugees with mental disorders is warranted. DECLARATION OF INTEREST: None. PMID: 31608856 [PubMed - as supplied by publisher]
Source: The British Journal of Psychiatry for Mental Science - Category: Psychiatry Tags: Br J Psychiatry Source Type: research
In conclusion, prior to mental health clinical practices, standardized patient simulation may help nursing students gain experience. PMID: 31609152 [PubMed - as supplied by publisher]
Source: Issues in Mental Health Nursing - Category: Nursing Tags: Issues Ment Health Nurs Source Type: research
Anyone know if it is normal to not receive replies to thank you notes post-interview? I had five interviews I felt really good about at my top choice, but then I sent thank you notes and only received two replies. I thought I connected with everyone pretty well, and the thank you notes were, in my opinion, well thought out and not too long (three paragraphs max), so I was hoping to hear back from all five, and needless to say it is driving me insane that I haven't heard back from all five. I... Thank You Note Anxiety
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pre-Medical - MD Source Type: forums
Publication date: Available online 14 October 2019Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Marjan Torabi, Ashraf Kazem, Mahshid AbdishahshahaniAbstractObjectiveThe aim of this study is to validate the edited version of FAS for the purpose of couples undergoing ART.Study designIn this cross-sectional study, the validity of the revised version of the FAS questionnaire was assessed by testing it on 212 couples volunteered to undergo ART. The revised version comprises 12 items from the original FAS version and 6 items added based on a survey interview conducted on infertile coup...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Conclusions The assessment of MS in HF patient-caregiver dyads is important to formulate interventions aimed at improving anxiety and depression in patients and caregivers.
Source: Journal of Cardiovascular Nursing - Category: Nursing Tags: ARTICLES: Heart Failure Source Type: research
Conclusion: Half of the patients reported moderate to severe pain at least once during cardiac electrophysiological procedures without analgosedation. However, on average, patients reported only low pain levels. Postinterventional derived data on discomfort reflect the peri-interventional situation.
Source: Journal of Cardiovascular Nursing - Category: Nursing Tags: ARTICLES: Cardiovascular Surgery Source Type: research
When someone has an addiction to Vicodin and is ready to become sober, there are many questions that may arise. These can include: Where should I go for treatment? How much will it cost? How long will treatment take? What is Vicodin withdrawal like? Since there are many unknowns when it comes to getting treatment for addiction, it is very important to do research and find out as much as you can. This way, you will feel more prepared when you enter treatment and will be able to become much more comfortable throughout the process. This includes knowing what to expect when you are detoxing from Vicodin and what it might feel...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Addiction to Pharmaceuticals Substance Abuse anxiety in withdrawal detox opioid opioids vicodin withdrawal symptoms Source Type: blogs
Publication date: Available online 14 October 2019Source: SteroidsAuthor(s): Josef Bulant, Martin Hill, Marta Velíková, Anna Yamamotová, Pavel Martásek, Hana Pape┼żováAbstractAnorexia nervosa (AN) is associated with various alterations including the dysfunction of the HPA axis and consequently the hypercortisolemia and deficit in sex hormones but the comprehensive evaluation of changes in circulating steroids during the hospitalization of AN patients is lacking. We investigated the effect of realimentation of women with AN during hospitalization on 45 circulating steroids, the relationshi...
Source: Steroids - Category: Drugs & Pharmacology Source Type: research
Authors: Schanzer B, Rivas-Grajales AM, Khan A, Mathew SJ Abstract Introduction: Generalized anxiety disorder (GAD) is a common and disabling psychiatric condition that affects 3% of the population and exacts significant costs to society if untreated. There are numerous treatment options available, but all have side effects, and none are reliably effective, hence there is a significant need for new medications. Areas Covered: The authors reviewed clinical Phase II and III studies listed on the and websites, 2007-present. Additional information was gathered from the study...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research
More News: Anxiety | Brain | Neurology | Psychiatry | Study