Peripheral Anti-inflammatory Cytokine Interleukin-10 Treatment Mitigates Interleukin-1 β - Induced Anxiety And Sickness Behaviors in Adult Male Rats.

Peripheral Anti-inflammatory Cytokine Interleukin-10 Treatment Mitigates Interleukin-1β - Induced Anxiety And Sickness Behaviors in Adult Male Rats. Behav Brain Res. 2019 Jun 10;:112024 Authors: Munshi S, Parrilli V, Rosenkranz JA Abstract Pro-inflammatory cytokines produce manifestations of sickness during inflammation, such as malaise and lethargy. They also contribute to effects of inflammation on mood. Anti-inflammatory cytokines counteract damage caused by inflammatory processes and can limit the severity of inflammation. However, very little is known about the role of anti-inflammatory cytokines in sickness and mood changes during immune activation. The purpose of this study was to determine if a prototypical anti-inflammatory cytokine, interleukin 10 (IL-10), can offset sickness behavior and anxiety caused by a pro-inflammatory cytokine, and whether IL-10 itself modifies anxiety. Rodent models of sickness display suppression of behavioral activity that may reflect lethargy or malaise, while models of anxiety display reduced exploration in several tasks. The effects of peripheral single dose of cytokines on open field exploration, social interaction and elevated plus maze (EPM) tests in adult male Sprague-Dawley rats were measured at 30 - 50 min post-treatment. The prototypical pro-inflammatory cytokine IL-1β (1 μg, i.p.) caused a decrease in locomotor activity indicative of sickness behavior, but disproportionately reduc...
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research

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