Mediastinal Rosai-Dorfman Disease with Widespread Lesions. When Surgical Biopsy is Needed

Publication date: Available online 14 June 2019Source: The Annals of Thoracic SurgeryAuthor(s): Simone Furia, Nazarena Nannini, Anna Pascarella, Cristiano BredaAbstractRosai-Dorfman disease (RDD) is a rare benign disorder of the histiocytes, affecting lymph-nodes in its classical form. Extranodal RDD is considered the uncommon subtype and potentially impairs all tissues as well as intrathoracic organs. In our report, a FDG-PET scan of a mediastinal mass infiltrating the lungs and of widespread lesions suggested the presence of a metastatic disease. Open thoracic biopsy was required for immunochemistry and histopathology. Mediastinal mass with lesions disseminated throughout the body is an unusual presentation of extranodal RDD that calls for a challenging differential diagnosis to rule out the suspicion of metastatic malignancy.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research