An efficient one-pot organocatalyzed synthesis of spiro[chroman-3,6'-furo[2,3-d] pyrimidine]-tetraones.

An efficient one-pot organocatalyzed synthesis of spiro[chroman-3,6'-furo[2,3-d] pyrimidine]-tetraones.
Comb Chem High Throughput Screen. 2013 Jan 28;
Authors: Ahadi S, Bazgir A
Abstract
An efficient synthesis of new spiro[chroman-3,6'-furo[2,3-d]pyrimidine]-tetraones by an organocatalyzed three-component condensation reaction of aldehydes, barbituric acids and 3-bromo-4-hydroxy-2H-chromen-2-one in refluxing acetic acid in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) is reported. We are hopeful that the products will lead to a wider range pharmacological and physiological activity.
PMID: 23363063 [PubMed - as supplied by publisher]

Source: Combinatorial Chemistry and High Throughput Screening - January 28, 2013 Category: Chemistry Authors: Ahadi S, Bazgir A Tags: Comb Chem High Throughput Screen Source Type: research