Association of a homozygous GCK missense mutation with mild diabetes

ConclusionsWe present the third case of homozygousGCK mutations associated with mild hyperglycemia, rather than PNDM. Our in ‐silico analyses support previous evidences suggesting that protein stability plays a role in determining clinical severity ofGCK mutations.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: CLINICAL REPORT Source Type: research

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Authors: Patil MB, Ragav ED Abstract Introduction: Type-2 Diabetes is a heterogeneous group of disorders characterized by variable degrees of insulin resistance, impaired insulin secretion, and increased glucose production. Obese diabetic patients have 13.5% more chances of developing diabetic complications compared to non - obese diabetic patients. Vitamin D has found to be deficient in diabetic patient and it's role in insulin regulation. Obese females are more prone to develop diabetic complications and hypovitaminosis-D. Materials and Method: Total of 156 female diabetic patients aged 30 to 60 years who are...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
This study aimed at estimating the prevalence of GDM among antenatal women attending a rural secondary care hospital in southern India and attempts to study associations between anthropometry, parental history, physical activity of pregnant women and GDM. Methods: A hospital based cross sectional study was done among 630 pregnant women who were screened with oral glucose tolerance test between 24 and 28 weeks of gestation based on IADPSG criteria. Risk factors for developing GDM were assessed by conducting home visits to 75 women diagnosed to have GDM and 150 randomly selected women without GDM. Results: Hospital b...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Authors: Bhagat AK, Bhardwaj H, Bhardwaj BL, Goyal S, Jaura S, Jain P Abstract Introduction: Cataract represents one of the most frequent eye complications in type 1 DM and type 2 DM patients; contrarily, acute cataract in young diabetic patients occurs very rarely. Only few cases with acute bilateral cataract - all relatively shortly after the diagnosis of type 1 DM have been reported. It can affect visual acuity from slight visual impairment to complete blindness. Although usually associated with chronic hyperglycaemia, it may also occur on rapid restoration of euglycaemia.1 Early detection of diabetes and adequa...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
 Movement Disorder - A Rare Presentation of Diabetic Ketoacidosis. J Assoc Physicians India. 2019 Apr;67(4):81-82 Authors: Garg S, Jain P, Sharma VK, Maheshwari S Abstract Abstract: Diabetic ketoacidosis is a common acute complication of Diabetes Mellitus. Diabetic ketoacidosis is known to cause impaired consciousness due to the osmolar and acid base imbalance which in turn cause central nervous system involvement. Here we report a rare presentation of Diabetic ketoacidosis with movement disorder in form of hemichorea and facial tics. The movement disorder improved with treatment of ketosis. P...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
 Targeting Glycemic Level in Gestational Diabetes Mellitus to that of Normal Pregnancy would result in a better Maternal-Fetal Outcome. J Assoc Physicians India. 2019 Apr;67(4):66-70 Authors: Seshiah V, Kapur A, Balaji V, Shah SN, Das AK, Diwakar H, Banerjee S, Anjalakshi C Abstract Abstract: Women with a history of Gestational Diabetes Mellitus (GDM) are at increased risk of future diabetes and related Non-Communicable Diseases (NCD) as are their offspring. "Transgenerational transmission occurs". Independent of genetic risk, offspring of hyperglycaemic pregnancies are at increased risk...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Conclusion: The blood pressure, sr. triglycerides, sr. high density lipids, fasting blood sugar were significant in cases as compared to controls satisfying the criteria of Adult Panel Treatment III (ATP III) of Metabolic Disorders. PMID: 31309797 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
 Study of Impact of Glycemic Status (HbA1c) on Platelet Activity measured by Mean Platelet Volume &Vascular Complications in Diabetics. J Assoc Physicians India. 2019 Apr;67(4):26-29 Authors: Saluja M, Swami YK, Meena SR Abstract Introduction: Diabetes mellitus is a global pandemic. The increased platelet activity may play a role in the development of vascular complications of this metabolic disorder. The mean platelet volume (MPV) is an indicator of the average size and activity of platelets. Larger platelets are younger and exhibit more activity. Aims and Objectives: To determine the MPV...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
ConclusionConsidering patients with chronic subdural hematomas our study demonstrated that the significant variables predicting outcome are chronic subdural hematomas occurring secondary to an overdraining ventriculo-peritoneal shunt, a history of seizures, and a low level of consciousness measured by either the Markwalder or the Glasgow Coma Score. Interestingly all of these variables are determined prior to the patient arriving at hospital. Our study highlights the need for early presentation prior to clinical deterioration as the major determinant of outcome.
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
We describe the implementation, clinical outcomes and participant perspectives for e-Healthystrides©. Setting: Three independent ambulatory clinics and an historic African American (AA) church. Participants: Adults with diagnosed diabetes mellitus type 2. Intervention: e-Healthystrides© health coach facilitated intervention. Primary outcome: Acquisition of three new self-management behaviors. Secondary outcomes: Blood pressure, blood glucose, A1c, attrition rate and participant perspectives of e-Healthystrides©. Methods: A convergent parallel mixed method design was used in both pilot...
Source: Ethnicity and Disease - Category: International Medicine & Public Health Tags: Ethn Dis Source Type: research
We aimed at evaluating whether the presence of gestational diabetes mellitus (GDM) in mothers is associated with increased risk of incident cardiovascular disease (CVD) in both mothers and fathers.
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
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