CT lung screening reduces cancer mortality most in women

CT lung cancer screening reduced cancer mortality by 69% in high-risk female...Read more on AuntMinnie.comRelated Reading: Risk models boost efficiency of CT lung cancer screening Prolonged CT lung screening offers cumulative benefits CT lung screening spots cancers earlier in China CT lung screening cuts cancer mortality 51% in Japan CT lung screening reduces cancer mortality in men by 26%
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news

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Conclusions: SIF + XRT caused changes in patterns of endothelial cell death and survival, proinflammatory molecule release, and adhesion molecule expression at early time points post-XRT associated with early reduction of immune cell recruitment. These findings suggest that SIF could mediate its radioprotective effects in irradiated lungs by limiting excessive immune cell homing via vascular endothelium into damaged lung tissue and curtailing the overall inflammatory response to radiation. PMID: 31633433 [PubMed - as supplied by publisher]
Source: International Journal of Radiation Biology - Category: Radiology Tags: Int J Radiat Biol Source Type: research
This study aimed to investigate how bevacizumab, a vascular endothelial growth factor A (VEGFA) neutralizing antibody applied in clinic, affects the tight junction protein CLDN5 and subsequently influences tumor cell invasion and potential metastasis. Western-blot, quantitative real-time polymerase chain reaction (q-PCR), immunofluorescence and immunohistochemistry revealed that low-dose bevacizumab up-regulated CLDN5, whereas high-dose bevacizumab down-regulated CLDN5. Cell migration, invasion and permeation assay demonstrated that high-dose bevacizumab enhanced the migration, invasion and permeation abilities of human um...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
Authors: Yang Y, Zheng H, Zhan Y, Fan S Abstract Traditionally, the metastasis has been detected in the late stage of the cancer, which mostly leads to death. The classical opinion about tumor metastasis is that tumor cell migration begins with the single tumor cell and goes through a series of complicated procedures, and lastly arrives and survives at distant tissues and organs. However, emerging studies have found a new migration mechanism called collective cell migration in many cancers. The collective cell migration could move as clusters with the tight cell-cell junction in the tumor microenvironments, toward ...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
In conclusion, our findings proved that XIST can serve as a tumor promoter in the pathogenesis of NSCLC, suggesting that XIST has the potential to become a novel therapeutic target for the treatment of NSCLC. PMID: 31632587 [PubMed]
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
In conclusion, our study found the critical regulation of lncRNA LINC00337 for the NSCLC through epigenetic regulation, which may serve as a predictive biomarker and potential therapeutic target. PMID: 31632575 [PubMed]
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
Authors: Kozuma Y, Toyokawa G, Yamada Y, Shoji F, Yamazaki K, Oda Y, Takeo S PMID: 31632774 [PubMed]
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Authors: Windisch P, Guckenberger M PMID: 31632771 [PubMed]
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Authors: Liam CK, Poh ME, Liam YS PMID: 31632766 [PubMed]
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Authors: Lamberti G, Andrini E, Ricciuti B PMID: 31632761 [PubMed]
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Authors: Kerdidani D, Magkouta S, Tsoumakidou M PMID: 31632820 [PubMed]
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
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