Effect of moxibustion on the expression of GDNF and its receptor GFR α3 in the colon and spinal cord of rats with irritable bowel syndrome.

Effect of moxibustion on the expression of GDNF and its receptor GFRα3 in the colon and spinal cord of rats with irritable bowel syndrome. Acupunct Med. 2019 Jun 12;:acupmed2017011455 Authors: Qi Q, Wu H, Jin X, Jin D, Wang Y, Wang C, Liu Y, Wang X Abstract BACKGROUND: Moxibustion treatment has been found to ameliorate clinical symptoms including abdominal pain, diarrhoea and constipation in patients with irritable bowel syndrome (IBS). Herein we investigated the mechanisms underlying the use of moxibustion in a rat model of IBS. METHODS: In our study, an IBS model was established in rats by colorectal distension (CRD) stimulus and mustard oil enema. The rats were randomly divided into a normal group, model group, mild moxibustion group, electroacupuncture group, probiotic group and dicetel group. Abdominal withdrawal reflex (AWR) scores were determined within 90 min of the last treatment. The expression of GDNF/GFRα3 protein and mRNA in the colon and spinal cord were detected by immunohistochemistry and quantitative real-time-PCR, respectively. RESULTS: The IBS model rats had significantly higher AWR scores than the normal group (P
Source: Acupuncture in Medicine : journal of the British Medical Acupuncture Society - Category: Complementary Medicine Authors: Tags: Acupunct Med Source Type: research

Related Links:

Conclusions: Results suggest TCC may have a small positive effect on early outcomes, but use of the services was highly variable among sites. Level of Evidence: Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
Source: Journal of Orthopaedic Trauma - Category: Orthopaedics Tags: Original Article Source Type: research
STOMACH bloating is usually remedied by making simple dietary changes. If quick fixes do not alleviate the tummy swelling, this may signal a more serious condition, including one that specifically affects women.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
The objective of this study was to assess respiratory muscle quality and function in DMD using magnetic resonance imaging and to determine the relationship to clinical respiratory function.MethodsIndividuals with DMD (n = 36) and unaffected controls (n = 12) participated in this cross sectional magnetic resonance imaging study. Participants underwent dynamic imaging of the thorax to assess diaphragm and chest wall mobility and chemical shift-encoded imaging of the chest and abdomen to determine fatty infiltration of the accessory respiratory muscles. Additionally, clinical pulmonary function mea...
Source: Journal of Neurology - Category: Neurology Source Type: research
Publication date: Available online 20 October 2019Source: The LancetAuthor(s): Daniel I Sessler, Lijian Pei, Yuguang Huang, Edith Fleischmann, Peter Marhofer, Andrea Kurz, Douglas B Mayers, Tanja A Meyer-Treschan, Martin Grady, Ern Yu Tan, Sabry Ayad, Edward J Mascha, Donal J Buggy, Gang Tan, Zhiyong Zhang, Helen Keane, Maurice Stokes, Oliver Zotti, Michael Gnant, Silvia Perez-ProttoSummaryBackgroundThree perioperative factors impair host defence against recurrence during cancer surgery: the surgical stress response, use of volatile anaesthetic, and opioids for analgesia. All factors are ameliorated by regional anaesthesia...
Source: The Lancet - Category: General Medicine Source Type: research
Conclusion: This qualitative study offers insight into the patient's perspective of dental hygienists administering LA. Participants supported dental hygienists administering LA and appreciated the aspects of patient-centered care that this practice provided. Patient participants were unclear on educational requirements and training, but supported legislation allowing dental hygienists to administer LA. PMID: 31628175 [PubMed - in process]
Source: Journal of Dental Hygiene - Category: Dentistry Tags: J Dent Hyg Source Type: research
Publication date: Available online 20 October 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): R. Sacco, S. Shah, R. Leeson, V. Moraschini, C.F. de Almeida Barros Mourão, O. Akintola, A. LalliAbstractTumour necrosis factor-α (TNF-α) inhibitors are increasingly being used as immunomodulators to manage inflammatory conditions such as rheumatoid arthritis and Crohn’s disease. Reported serious side effects include an increased incidence of lymphoma and greater susceptibility to infections such as tuberculosis. The aim of this systematic review was to find out whether there is an ...
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Authors: Chimed-Ochir O, Mine Y, Fujino Y Abstract OBJECTIVES: The current research aimed to study the relationship between health-related quality of life (poor perceived health/unhealthy days) and workers' pain. METHODS: This cross-sectional study was conducted among 1360 Japanese workers of a Japanese company in Kyushu. Health-related quality of life was measured by HRQOL-4 tool developed by Centers for Disease Control and Prevention of the USA. Pain was assessed by numeric rating scale with 0-10 points. Regression analysis was conducted to identify the relationship between health-related quality of life and ...
Source: Journal of Occupational Health - Category: Occupational Health Tags: J Occup Health Source Type: research
AbstractPurposeThe oldest old, described as those aged 85 and older, is a growing cancer population. There are limited studies evaluating the symptoms of the oldest old cancer patient population. Our study aimed to evaluate symptom frequency and clinical symptom change as assessed by the Edmonton Symptom Assessment System (ESAS) of the oldest old ( ≥ 85) compared to older adult (65–84) and general adult (18–64) outpatient cancer patients on initial consult and follow-up visit.MethodsRetrospective review of a total of 441 patients, 200 randomly sampled patients in the general and older adult group and ...
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
This article aims to evaluate the effectiveness, security, and performance difficulty of GIB in patients with pelvic and perineal oncological pain.MethodsA retrospective study between January 2016 and August 2017. Patients with poorly controlled pelvic oncological pain and patients experimenting opioid side effects in which GIB was performed ambulatory were included. Prognostic GIB was performed, under echographic and fluoroscopic control, with local anesthetic and corticoid. The neurolytic block was performed under fluoroscopic guidance. The technique was performed by the same anesthetist with pain management competence. ...
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
ConclusionESWT is a safe and relevant modality for the supportive care and rehabilitation of cancer patients.
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
More News: Acupuncture | Back Pain | Brain | Complementary Medicine | Constipation | Diarrhoea | Irritable Bowel Syndrome | Neurology | Pain | Probiotics | Reflex Sympathetic Dystrophy | Study | UK Health