Control of Gram-negative multi-drug resistant microorganisms in an Italian ICU: Rapid decline as a result of a multifaceted intervention, including conservative use of antibiotics

Acutely ill patients assisted in the Intensive Care Unit (ICU) are at high risk of both colonization and infection with Multidrug Resistant Organisms (MDROs) (Huskins, 2007; Landelle et al., 2014). Selection of MDROs in these patients may occur either as a consequence of prolonged exposure of resident microflora to wide spectrum antibiotic pressure (Bassetti et al., 2017; Meyer et al., 2010), or by nosocomial transfer (Richards et al., 1999; Warren et al., 2004). In recent years, an increased prevalence of Gram-negative bacteria with reduced or even absent sensitivity to currently available antibiotics (Gram-negative Multi-Drug-Resistant Organisms, GNMDROs) has been reported (Li et al., 2006; Sligl et al., 2015).

Source: International Journal of Infectious Diseases - June 14, 2019 Category: Infectious Diseases Authors: Antonella Frattari, Vincenzo Savini, Ennio Polilli, Graziano Di Marco, Giuseppe Lucisano, Serena Corridoni, Tullio Spina, Alberto Costantini, Antonio Nicolucci, Paolo Fazii, Pierluigi Viale, Giustino Parruti Source Type: research