Improved Clinical Outcome After Treatment of Mycobacterium abscessus Complex Pulmonary Disease in Children With Cystic Fibrosis
The objectives of this study were to characterize the clinical outcomes and clearance of Mycobacterium abscessus complex (M. abscessus) from respiratory cultures in children with CF M. abscessus PD. Methods: This retrospective longitudinal cohort analysis evaluated the first course of treatment for M. abscessus PD in 33 children in Queensland, Australia between 2001 and 2015. Spirometry and nutritional outcomes 2 years pretreatment and 1 year posttreatment were compared with clearance or relapse/persistence of Mycobacterium abscessus complex from respiratory cultures. Results: Nine of 18 children who completed therapy, cleared infection. Three of 7 children who completed only intensive therapy cleared sputum compared with 0/8 children who did not. The trajectory of the percent predicted forced expiratory volume in 1 s and age standardized body mass index significantly improved posttreatment in those that cleared sputum (P
ConclusionsSPX-101 was well-tolerated across a range of doses and had little/no systemic exposure in healthy adults and adults with CF, thus supporting further study in patients with CF.Clinicaltrial.gov registrationNCT03056989.
CONCLUSION: After more than a decade, lung MRI has become a valuable tool for monitoring CF in clinical routine application and as an endpoint for clinical studies. PMID: 31172247 [PubMed - as supplied by publisher]
In adult patients with cystic fibrosis (CF) fraction of exhaled nitric oxide (FeNO) has been reported to be normal or abnormally low . FeNO has also been reported to correlate with spirometry [2–4], and to increase following treatment with ivacaftor [5, 6], suggesting that FeNO could be used as a noninvasive, fast and easily available marker of CFTR-function. The aim of this study was to examine whether in adult CF patients, FeNO was associated with patient characteristics and lung function, and whether FeNO was affected by acute exacerbation. We also aimed to examine FeNO evolution over a longer period after star...