Acalabrutinib for mantle cell lymphoma

Mantle cell lymphoma (MCL) is a unique type of non-Hodgkin lymphoma characterized by the overexpression of cyclin D1. MCL patients typically live for years but experience multiple relapses. Acalabrutinib is a novel second-generation oral Bruton tyrosine kinase inhibitor approved by the US Food and Drug Administration for relapsed MCL based on a clinical trial demonstrating an overall response rate of 81%. It provides a valuable new treatment option for MCL patients and is now being tested upfront.

Source: Blood - June 12, 2019 Category: Hematology Authors: Witzig, T. E., Inwards, D. Tags: Lymphoid Neoplasia, Blood Spotlight Source Type: research