Inhibition of ATP binding cassette transporter B1 sensitizes human hair follicles to chemotherapy-induced damage

Hair follicles (HFs) are sensitive to xenobiotic damage, which can ultimately lead to hair loss such as in chemotherapy-induced alopecia (CIA) [1]. Members of the ATP-binding cassette (ABC) transporter family fulfil a crucial role in xenobiotic, where they actively extrude drugs thereby reducing intracellular drug accumulation and limiting cellular toxicity [2]. Recently, we demonstrated that human scalp hair follicles (HFs) express an array of ABC transporter proteins, many of which localise to the anagen hair matrix (HM) and the bulge [3].

Source: Journal of Dermatological Science - June 12, 2019 Category: Dermatology Authors: Ellie Smart, Nilofer Farjo, Bessam Farjo, Iain S Haslam, Ralf Paus Source Type: research