Differential Activation of Fetal Hofbauer Cells in Primigravidas Is Associated with Decreased Birth Weight in Symptomatic Placental Malaria.

Conclusions: Placentas with malarial infection had increased numbers of fetal Hofbauer cells in the villous stroma and maternal macrophages in the intervillous space. In primigravidas, decreased anti-inflammatory M2-type Hofbauer cells were predictive of lower birth weight. M2-type maternal macrophages were increased in placental malaria, but there was no association with gravidity or birth weight. These results suggested a protective role of M2 Hofbauer cells in fetal growth restriction. PMID: 31186834 [PubMed]

https://www.ncbi.nlm.nih.gov/pubmed/31186834?dopt=Abstract

Source: Cell Research - June 14, 2019 Category: Cytology Authors: Gaw SL, Hromatka BS, Ngeleza S, Buarpung S, Ozarslan N, Tshefu A, Fisher SJ Tags: Malar Res Treat Source Type: research