T lymphocyte dependence of the immune response to immunosuppressive neoantigen-exposing Fc fragments of IgG.

T lymphocyte dependence of the immune response to immunosuppressive neoantigen-exposing Fc fragments of IgG. J Biol Regul Homeost Agents. 2019 Jun 11;33(3) Authors: Stolyarova E, Beduleva L, Menshikov I, Sidorov A, Khramova T Abstract Our recent studies have identified a new factor in the negative immunoregulation that prevents experimental autoimmune diseases (1). This factor was shown to be anti-idiotypic antibodies to lymphocytes against autoimmune disease-inducing antigens; at the same time, it is specific for neoepitopes on papain Fc fragments of homologous IgG (1). Because of its specificity to Fc fragments, we designated this regulatory factor "regulatory rheumatoid factor" (regRF) (2). Immunization with IgG Fc fragments that expose epitopes recognized by regRF reduces collagen-induced arthritis (CIA) in rats (2). These characteristics indicate that regRF-producing lymphocytes may serve as a therapeutic biotarget, and the Fc fragments that expose epitopes recognized by regRF may be a promising therapeutic agent for rheumatoid arthritis. We noted that the regRF production induced by immunization with Fc fragments is always rapid and brief (2). RegRF peaks on day 7 post-immunization; by day 14 it has returned to the initial level. The characteristics of regRF production kinetics cannot be explained, because the mechanisms by which the system regulates autoimmunity with the involvement of regRF, particularly the mechanisms by whi...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research