Acute prazosin administration does not reduce stressor reactivity in healthy adults

ConclusionsFurther research is needed to determine whether this failure to translate preclinical neuroscience to human laboratory models is due to methodological factors (e.g., acute vs. chronic drug administration, brain penetration, study population) and/or suggests limited clinical utility of noradrenergic alpha-1 antagonists for treating stress-related psychiatric disorders.

Source: Psychopharmacology - June 12, 2019 Category: Psychiatry Source Type: research