Structural consequences of transforming growth factor beta-1 activation from near-therapeutic X-ray doses

Dissociation of transforming growth factor beta-1 (TGF β -1) from the inhibitory protein latency-associated peptide (LAP) can occur from low doses of X-ray irradiation of the LAP – TGF β -1 complex, resulting in the activation of TGF β -1, and can have health-related consequences. Using the tools and knowledge developed in the study of radiation damage in the crystallographic setting, small-angle X-ray scattering (SAXS) and complementary techniques suggest an activation process that is initiated but not driven by the initial X-ray exposure. LAP is revealed to be extended when not bound to TGF β -1 and has a different structural conformation compared to the bound state. These studies pave the way for the structural understanding of systems impacted at therapeutic X-ray doses and show the potential impact of radiation damage studies beyond their original intent.
Source: Journal of Synchrotron Radiation - Category: Physics Authors: Tags: latency-associated peptide transforming growth factor beta-1 SAXS radiation damage research papers Source Type: research
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