Loss of ABAT-Mediated GABAergic System Promotes Basal-Like Breast Cancer Progression by Activating Ca2+-NFAT1 Axis

Conclusions: Our findings have provided underlying molecular details for the aggressive behavior of BLBC. The Snail-mediated downregulation of ABAT expression in BLBC provides tumorigenic and metastatic advantages by activating GABA-mediated Ca2+-NFAT1 axis. Thus, our results have identified potential prognostic indicators and therapeutic targets for this challenging disease.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research

Related Links:

The objective of this analysis was to assess the pharmacokinetics of pertuzumab in combination with trastuzumab in Chinese patients with early breast cancer. Samples for pertuzumab and trastuzumab pharmacokinetic analysis were taken from Chinese patients during cycle 1 of treatment and at steady-state in cycle 10. Noncompartmental analysis was used to estimate minimum and maximum serum concentrations (Cmax and Cmin), area under the concentration-time curve, clearance, and other pharmacokinetic parameters. In 15 patients, mean steady-state Cmax and Cmin pertuzumab serum concentrations (368 ± 177 μg/ml, and 122 &pl...
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Clinical Papers Source Type: research
Authors: Hamdan D, Nguyen TT, Leboeuf C, Meles S, Janin A, Bousquet G Abstract Breast cancer remains a major health issue in the world with 1.7 million new cases in 2012 worldwide. It is the second cause of death from cancer in western countries. Genomics have started to modify the treatment of breast cancer, and the developments should become more and more significant, especially in the present era of treatment personalization and with the implementation of new technologies. With molecular signatures, genomics enabled a de-escalation of chemotherapy and personalized treatments of localized forms of estrogen-depend...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Condition:   Breast Neoplasms Intervention:   Drug: Taxanes or/and anthracycline-based therapy Sponsor:   Shengjing Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Dignitana, a company out of Lund, Sweden, won FDA clearance and is now distributing its DigniCap Delta scalp cooling system in the U.S. The University of California, San Francisco (UCSF) will be the first recipient in America of the fourth generation...
Source: Medgadget - Category: Medical Devices Authors: Tags: Medicine Oncology Source Type: blogs
Authors: Eysel P, Baltin C, Meyer C Abstract A 59-year-old woman with breast cancer who had undergone chemotherapy, three surgical interventions at the thoracic spine, and radiation since 2012, suffered from progressive ataxia caused by a single relapse metastasis resulting in spinal stenosis at thoracic level 6. Therefore, excessive tumour debulking was performed at thoracic levels 4 to 7 and a fully covered, self-expandable stent was placed around the spinal cord at these levels in order to create a mechanical barrier and to prevent the spinal cord from compression by the tumour. Neuromonitoring was performed bef...
Source: Zeitschrift fur Orthopadie und Unfallchirurgie - Category: Orthopaedics Tags: Z Orthop Unfall Source Type: research
Source: Clinical Nutrition - Category: Nutrition Authors: Tags: Nutritional assessment I Source Type: research
ConclusionsPercutaneous endoscopy allowed us to approach the psoas and epidural abscesses directly, enabling the immediate drainage of the abscesses with less burden on the patient.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Conclusions: Collagen degradation markers are associated with response to neoadjuvant therapy and seem to play a role in breast cancer.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Publication date: Available online 13 August 2019Source: European Journal of Surgical OncologyAuthor(s): Carlos A. Garcia-Etienne, Alberta Ferrari, Angelica Della Valle, Marco Lucioni, Elisa Ferraris, Giuseppe Di Giulio, Luigi Squillace, Elisabetta Bonzano, Angioletta Lasagna, Gianpiero Rizzo, Richard Tancredi, Andrea Scotti Foglieni, Francesca Dionigi, Maurizia Grasso, Eloisa Arbustini, Giorgio Cavenaghi, Paolo Pedrazzoli, Andrea R. Filippi, Paolo Dionigi, Adele SgarellaAbstractThe surgical approach to the axilla in breast cancer has been a controversial issue for more than three decades. Data from recently published tria...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
ConclusionOsteopathy does not reduce the incidence of nausea/vomiting in women operated for breast cancer and undergoing adjuvant chemotherapy. In contrast, patient reported digestive quality of life was significantly ameliorated by osteopathy. Clinicaltrials.gov Identifier: NCT02840890.
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
More News: Breast Cancer | Cancer | Cancer & Oncology | Chemotherapy | Molecular Biology