Loss of ABAT-Mediated GABAergic System Promotes Basal-Like Breast Cancer Progression by Activating Ca2+-NFAT1 Axis
Conclusions: Our findings have provided underlying molecular details for the aggressive behavior of BLBC. The Snail-mediated downregulation of ABAT expression in BLBC provides tumorigenic and metastatic advantages by activating GABA-mediated Ca2+-NFAT1 axis. Thus, our results have identified potential prognostic indicators and therapeutic targets for this challenging disease.
Source: Theranostics - Category: Molecular Biology Authors: Xingyu Chen, Qianhua Cao, Ruocen Liao, Xuebiao Wu, Shining Xun, Jian Huang, Chenfang Dong Tags: Research Paper Source Type: research