MiR-454-3p-Mediated Wnt/ β -catenin Signaling Antagonists Suppression Promotes Breast Cancer Metastasis

Conclusions: The findings indicate that miR-454-3p-mediated suppression of Wnt/β-catenin antagonist RPRD1A, as well as AXIN2, DKK3 and SFRP1, sustains the constitutive activation of Wnt/β-catenin signaling; thus, miR-454-3p and RPRD1A might be potential diagnostic and therapeutic targets for breast cancer metastasis.

Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Liangliang Ren, Han Chen, Junwei Song, Xuhong Chen, Chun Lin, Xiaolan Zhang, Ning Hou, Jinyuan Pan, Zhongqiu Zhou, Lan Wang, Danping Huang, Jianan Yang, Yingying Liang, Jun Li, Hongbiao Huang, Lili Jiang Tags: Research Paper Source Type: research