miR-26a Limits Muscle Wasting and Cardiac Fibrosis through Exosome-Mediated microRNA Transfer in Chronic Kidney Disease

Conclusion: Overexpression of miR-26a in muscle prevented CKD-induced muscle wasting and attenuated cardiomyopathy via exosome-mediated miR-26a transfer. These results suggest possible therapeutic strategies for using exosome delivery of miR-26a to treat complications of CKD.

Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Bin Wang, Aiqing Zhang, Haidong Wang, Janet D. Klein, Lin Tan, Ze-Mu Wang, Jie Du, Nawazish Naqvi, Bi-Cheng Liu, Xiaonan H. Wang Tags: Research Paper Source Type: research