HOXB13 networking with ABCG1/EZH2/Slug mediates metastasis and confers resistance to cisplatin in lung adenocarcinoma patients

Conclusions: A cisplatin-HOXB13-ABCG1/EZH2/Slug network may account for a novel mechanism underlying cisplatin resistance and metastasis after chemotherapy. Determining the levels of HOXB13 and its target genes from needle biopsy specimens may help predict the sensitivity of lung adenocarcinoma patients to platinum-based chemotherapy and patient outcomes.

Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Jun Zhan, Peng Wang, Shuai Li, Jiagui Song, Huiying He, Yunling Wang, Zhaofei Liu, Fan Wang, Hua Bai, Weigang Fang, Quan Du, Min Ye, Zhijie Chang, Jie Wang, Hongquan Zhang Tags: Research Paper Source Type: research