Induction of nuclear protein-1 by thyroid hormone enhances platelet-derived growth factor A mediated angiogenesis in liver cancer

Conclusions: We propose that the T3/TR/NUPR1/PDGFA/MEK/ERK axis has a vital role in hepatocarcinogenesis and suggest NUPR1 as a potential therapeutic target in HCC.

Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Ching-Ying Chen, Sheng-Ming Wu, Yang-Hsiang Lin, Hsiang-Cheng Chi, Syuan-Ling Lin, Chau-Ting Yeh, Wen-Yu Chuang, Kwang-Huei Lin Tags: Research Paper Source Type: research