Imaging fibrosis in inflammatory diseases: targeting the exposed extracellular matrix

Conclusion: Imaging of 64Cu-GPVI-Fc accumulation in the ECM matrix appears to be a promising candidate for monitoring chronic inflammation. By binding to exposed fibrous tissue (collagen, fibronectin, etc.) after extravasation, a new insight is provided into the fibrotic events resulting from a prolonged inflammatory state.

Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Nicolas Beziere, Kerstin Fuchs, Andreas Maurer, Gerald Reischl, J ü rgen Br ü ck, Kamran Ghoreschi, Birgit Fehrenbacher, Daniel Carvajal Berrio, Katja Schenke-Layland, Ursula Kohlhofer, Leticia Quintanilla-Martinez, Meinrad Gawaz, Manfred Kneilling, Ber Tags: Research Paper Source Type: research