Nerve modulation therapy in gouty arthritis: targeting increased sFRP2 expression in dorsal root ganglion regulates macrophage polarization and alleviates endothelial damage

Conclusion: We demonstrated the involvement of a sensory neuron-macrophage axis in GA pathology that was regulated by sFRP2 expression in a paracrine manner. Targeting increased sFRP2 expressions in DRG provide novel insights for future GA research in both pain alleviation and treatment of gout inflammation.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research

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This study used Oswestry Disability Index (ODI)-self-comparison and showed that acupuncture treatments for lumber disc herniation and sciatica demonstrated significant improvement in long term clinical outcomes. A total of 112 lumbar disc herniation and sciatica cases were treated with electric acupuncture for pain relief and function improvement from July 1998 to December 2006.ResultsAll the 112 cases filled out the ODI forms prior to receiving treatment. Among the 112 patients, 23 of them did not finish the 6-week treatments. 89 cases were evaluated with ODI after 6-week acupuncture treatments. Of those 89 cases, 67 case...
Source: World Journal of Acupuncture Moxibustion - Category: Complementary Medicine Source Type: research
Publication date: Available online 18 July 2019Source: Best Practice &Research Clinical AnaesthesiologyAuthor(s): Alan David Kaye, Mark W. Motejunas, Lauren A. Bonneval, Ken P. Ehrhardt, Dustin R. Latimer, Andrea Trescot, Kyle E. Wilson, Ibraham N. Ibrahim, Elyse M. Cornett, Richard D. Urman, Kenneth D. CandidoAbstractChronic pain management techniques have evolved in recent years. In this regard, ultrasound technology has become a standard for most acute pain procedures and essential for postsurgical pain relief and enhanced recovery after surgery protocols. This manuscript summarizes clinical studies evaluating ultra...
Source: Best Practice and Research Clinical Anaesthesiology - Category: Anesthesiology Source Type: research
Publication date: Available online 17 July 2019Source: Best Practice &Research Clinical AnaesthesiologyAuthor(s): Henry Liu, Patrick I. Emelife, Amit Prabhakar, Vanessa Moll, Julia B. Kendrick, Allan T. Parr, Farees Hyatali, Thakur Pankaj, Jinlei Li, Elyse M. Cornett, Richard D. Urman, Charles J. Fox, Alan D. KayeAbstractPain is a significant consequence of cardiac surgery and newer techniques in cardiac anesthesia have provided an impetus for the development of multimodal techniques to manage acute pain in this setting. In this regard, regional anesthesia techniques have been increasingly used in many cardiac surgical...
Source: Best Practice and Research Clinical Anaesthesiology - Category: Anesthesiology Source Type: research
Authors: Liu J, Bhuvanagiri S, Qu X Abstract The aim of the present study was to investigate the effect of Lycopus lucidus Turcz (LT) on diabetic retinopathy (DR) and its underlying mechanisms. SD rats and human retinal microvascular endothelial cells (HRECs) were applied for establishment DR model. HE and TUNEL staining were used to evaluate the pathological changes and apoptosis of retinal ganglion cells. Additionally, retinal vessels were detected by immunofluorescence staining with CD31 and VEGF. The function of BRB was observed using Evans blue. Moreover, the oxidative stress, inflammation and angiogenesis ass...
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
Abstract Fascioliasis is a food-borne anthropozoonotic disease caused by Fasciola hepatica that affects multiple hosts, including humans. We herein report the first case of human fascioliasis in the state of Santa Catarina, Brazil. A 57-year-old female patient complaining of abdominal pain was admitted to the hospital for a clinical investigation. The diagnosis of F. hepatica was confirmed by ultrasound and indirect enzyme-linked immunosorbent assay. Authorities of the Northern coast of Santa Catarina were notified to investigate other cases and risk factors for contamination. The disease is also prevalent in cattle, which...
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research
Authors: Vinck EE, Villarreal RA, Luna-Jaspe C, Cabrera LF, Peterson TF, Bernal F, Roa CL Abstract Background: The intra-operative classification of appendicitis defines postoperative treatment. The correct designation can influence patient recovery, complications and hospital costs. Recent research has shown that intra-operative classification criteria varies among surgeons, and is not always the same as the pathologist's report. Classification accuracy can lower costs by preventing unnecessary treatment or sub-optimal interventions. Methods: During a period of 4 months, N = 133 appendix specimens we...
Source: Acta Chirurgica Belgica - Category: Surgery Tags: Acta Chir Belg Source Type: research
The Washington Post recently received access to a database maintained by the Drug Enforcement Administration that tracks the manufacture and distribution of every prescription opioid in the country. It  reported that 76 billion pills were distributed throughout the US between 2006 and 2012, with higher volumes shipped to the areas that were most hard hit with opioid-related overdose deaths. This is being offered as proof that the overprescribing of prescription opioids caused the overdose crisis. But this flies in the face of other powerful evidence. Research reported in the  Journal of Pain Research&nb...
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
Authors: Paul R, Nandi A, Roy D, Ghosh R, Sau TJ, Thakur I, Sarkar R Abstract Rheumatoid arthritis (RA) is a multisystem disease with a variety of manifestations. Vasculitis and myositis are two very rare complications of RA. However, the coexistence of both of these complications in the same patient is extremely rare in medical literature. We here present such a rare association of clinical features in a 36 year old male patient with RA. He had RA for around four years before development of these complications almost simultaneously. The patient was treated with rituximab and oral steroids. The myositis component r...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Authors: Bhushan D, Agarwal M Abstract Guaiacum is a homeopathic medicine used for arthritis, syphilis and tonsillitis. Its use as a substance abuse is not properly described in literature. Its excess intake may be life threatening and can damage the vision permanently. PMID: 31311227 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Conclusions: Poisoning was predominant in unmarried young males from lower economic class. The most common type of poisoning was suicidal, route was oral and agent was chemicals. Vomiting and pain in abdomen were the most common clinical features. Chemical poisoning was highly associated with renal failure and aspiration chemical pneumonitis requiring ventilator support and high mortality. Chemical agent of poisoning, Intravenous route of poisoning, requirement of mechanical ventilation, duration of hospital stay were significantly associated with mortality. PMID: 31311221 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
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