Cysteine-type cathepsins promote the effector phase of acute cutaneous delayed-type hypersensitivity reactions

Conclusion: Cathepsin B is actively involved in the effector phase of acute cutaneous DTHR. Thus, topically applied cathepsin B inhibitors might effectively limit DTHR such as contact dermatitis or psoriasis. However, the cathepsin B and Z knockout mouse experiments suggested a complementary role for these two cysteine-type proteases.

Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Johannes Schwenck, Andreas Maurer, Birgit Fehrenbacher, Roman Mehling, Philipp Knopf, Natalie Mucha, Dennis Haupt, Kerstin Fuchs, Christoph M. Griessinger, Daniel Bukala, Julia Holstein, Martin Schaller, Irene Gonzalez Menendez, Kamran Ghoreschi, Leticia Tags: Research Paper Source Type: research