Contribution of astrocytes to metabolic dysfunction in the Alzheimer's brain.

Contribution of astrocytes to metabolic dysfunction in the Alzheimer's brain. Biol Chem. 2019 Jun 01;: Authors: Zulfiqar S, Garg P, Nieweg K Abstract Historically considered accessory cells to neurons, there is an increasing interest in the role of astrocytes in normal and pathological conditions. Astrocytes are involved in neurotransmitter recycling, antioxidant supply, ion buffering and neuroinflammation i.e. a lot of the same pathways that go astray in Alzheimer's Disease (AD). AD remains the leading cause of dementia in the elderly, one for which there is still no cure. Efforts in AD drug development have largely focused on treating neuronal pathologies that appear relatively late in the disease. The neuroenergetic hypothesis, however, focuses on the early event of glucose hypometabolism in AD, where astrocytes play a key role, caused by an imbalanced neuronastrocyte lactate shuttle. This further results in a state of oxidative stress and neuroinflammation, thereby compromising the integrity of astrocyte-neuron interaction. Compromised astrocytic energetics also enhance amyloid generation, further increasing the severity of the disease. Additionally, apolipoprotein E (APOE), the major genetic risk factor for AD, is predominantly secreted by astrocytes and plays a critical role in amyloid clearance and regulates glucose metabolism in an amyloid-independent manner. Thus, boosting the neuroprotective properties of astrocytes has potential applications in...
Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research

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Increased Neuronal Nuclear and Perikaryal Size in the Medial Mamillary Nucleus of Vascular Dementia and Alzheimer's Disease Patients: Relation to Nuclear Estrogen Receptor α. Dement Geriatr Cogn Disord. 2019 Jul 18;:1-7 Authors: Ishunina TA, Bogolepova IN, Swaab DF Abstract BACKGROUND: The hypothalamic medial mamillary (MMN) and the tuberomamillary (TMN) nuclei are important hubs in memory circuits. Previous studies determining the neuronal Golgi complex size showed decreased metabolic activity of the TMN neurons in both Alzhei-mer's disease (AD) and vascular dementia (VD), and no obvious decline...
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
In this study, we verify the impact of CDIP parameters compliance on total brain volume variance using 86 scans of the same individual acquired on various scanners. Data included planned data collection acquired within the Consortium pour l'identification précoce de la maladie Alzheimer - Québec (CIMA-Q) and Canadian Consortium on Neurodegeneration in Aging (CCNA) studies, as well as opportunistic data collection from various protocols. For images acquired from Philips scanners, lower variance in brain volumes were observed when the stated CDIP resolution was set. For images acquired from GE scanners, lower v...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
This article is excerpted from Roberts &Kreuz’s book “Becoming Fluent: How Cognitive Science Can Help Adults Learn a Foreign Language.” This article originally appeared on MIT Press Reader. Read the original article here.  
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Aging syndication Source Type: news
Swedish and Canadian researchers have developed a four-stage model that uses...Read more on AuntMinnie.comRelated Reading: PET shows how women are more susceptible to Alzheimer's Florbetapir-PET links lack of financial acumen to dementia IDEAS study confirms amyloid PET's value for Alzheimer's Are amyloid PET scans ready for the clinical setting? PET links sleep and beta-amyloid accumulation
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Publication date: July 2019Source: Alzheimer's &Dementia, Volume 15, Issue 7Author(s): Zaven S. Khachaturian, Lewis H. Kuller, Ara S. Khachaturian
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
This article summarizes the evidence for translation into action.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
DiscussionEducation did not convey differential survival advantages to individuals with higher genetic risk of AD, but may reduce hospitalization risk associated with AD genetic risk.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Publication date: July 2019Source: Alzheimer's &Dementia, Volume 15, Issue 7Author(s):
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Publication date: July 2019Source: Alzheimer's &Dementia, Volume 15, Issue 7Author(s):
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Publication date: July 2019Source: Alzheimer's &Dementia, Volume 15, Issue 7Author(s):
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
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