Wnt/Β-catenin signaling pathway regulates tumor-initiating cells in head and neck squamous cell carcinoma

ConclusionsActivation of Wnt/β-catenin signaling pathway is an early event in HNSCC carcinogenesis. Lineage tracing using the Axin2-CreER reporter may link TICs properties with a fundamental signaling pathway in normal development. Further research is required to clarify the role of Wnt-responsive TICs in recurrence and therapy resistance of HNSCC.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research