Ameloblastoma arising in odontogenic keratocyst: report of four rare cases, immunohistochemical analysis and review of literature

Publication date: July 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 128, Issue 1Author(s): Dr. Moni Ahmadian, Dr. Paul Freedman, Dr. Renee ReichOdontogenic keratocyst (OKC) is a developmental cyst of the gnathic bones arising from the rests of dental lamina. This cyst demonstrates propensity for aggressive behavior and a relative high rate of recurrence compared to the other odontogenic cysts. Ameloblastoma is a benign neoplasm of odontogenic epithelium. It is the most common clinically significant odontogenic tumor that may demonstrate a locally aggressive clinical behavior. Ameloblastoma may theoretically arise de novo from the rests of dental lamina as well as a developing enamel organ or from the epithelial lining of a pre-existing odontogenic cyst. Rare cases of ameloblastoma arising in the wall of dentigerous cyst, calcifying odontogenic cyst, glandular odontogenic cyst, radicular cyst, and residual cyst have been previously documented in the existing literature. Furthermore, ameloblastomatous changes of cysts in nevoid basal cell carcinoma syndrome (NBCCS) have been previously reported. To our knowledge, only one case of ameloblastoma combined with an OKC in a non-syndromic patient has been reported in the English language literature so far. Here we report four additional and extremely rare instances of ameloblastoma arising in combination with an OKC. Microscopically, all the cases exhibit the distinctive histopathologic features ...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research

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os AC Abstract PURPOSE: To examine the effects of Arrabidaa chica (Bignoniacea) extract, a native plant of the Amazon known as crajiru, on a 7,12-dimethyl-1,2-benzanthracene (DMBA)-induced breast cancer model in Wistar rats. METHODS: We compared the response of breast cancer to the oral administration of A. chica extract (ACE) for 16 weeks, associated or not with vincristine. Groups: normal control; DMBA (50mg/kg v.o,) without treatment; DMBA+ACE (300 mg/kg); DMBA+vincristine. 500μg/kg injected i.p; DMBA+ACE+Vincristine 250μg/kg i.p. Imaging by microPET and fluorescence, biochemistry, oxidative stress, ...
Source: Acta Cirurgica Brasileira - Category: Surgery Authors: Tags: Acta Cir Bras Source Type: research
Authors: Chornoguz O, Leettola CN, Leander K, Brosnan K, Emmell E, Chiu ML, Santulli-Marotto S Abstract Although CD3 T cell redirecting antibodies have been successfully utilized for the treatment of hematological malignancies (blinatumomab), the T cell signaling pathways induced by these molecules are incompletely understood. To gain insight into the mechanism of action for T cell redirection antibodies, we created a novel murine CD3xEpCAM bispecific antibody that incorporates a silent Fc to dissect function and signaling of murine CD8 OT1 T cells upon stimulation. T cell-mediated cytotoxicity, cytokine secretion,...
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - Category: Microbiology Tags: Monoclon Antib Immunodiagn Immunother Source Type: research
This study is registered with Clinicaltrials.gov, number NCT02560025, and has completed enrolment.FindingsBetween Dec 31, 2015, and Aug 1, 2017, we enrolled a total of 39 eligible patients. 19 (49%) of 39 patients had secondary acute myeloid leukaemia and three (8%) had therapy-related acute myeloid leukaemia. At mid-induction, 33 (85%) of 39 patients showed marrow aplasia, six (15%) received re-induction. The median follow-up was 13·7 months (IQR 12·7–14·4). Composite remission was 64% (two-stage 95% CI 48–79), with 20 (51%) of 39 patients achieving complete remission and five (13%) achiev...
Source: The Lancet Haematology - Category: Hematology Source Type: research
Abstract BACKGROUND AND OBJECTIVES: Citrus fruit are suggested to be associated with reduced risk of nasopharyngeal carcinoma (NPC), but findings from epidemiologic studies have been inconsistent. We aimed to synthesize the association by conducting a meta-analysis of existing evidence. METHODS AND STUDY DESIGN: Databases including Medline, EMBASE, Web of science, and the Cochrane Library were searched for eligible studies up to March 2019 using a series comprehensive searching terms. The adjusted odds ratios (ORs) of citrus fruit intake with NPC risk from each study were extracted to calculate a pooled assoc...
Source: Asia Pacific Journal of Clinical Nutrition - Category: Nutrition Authors: Tags: Asia Pac J Clin Nutr Source Type: research
Publication date: December 2019Source: British Journal of Oral and Maxillofacial Surgery, Volume 57, Issue 10Author(s): Rajat Paul, Satheesh Prabhu
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Publication date: December 2019Source: British Journal of Oral and Maxillofacial Surgery, Volume 57, Issue 10Author(s): James Edwin Crawford, Gabriele Baniulyte, Jeremy McMahon
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Publication date: December 2019Source: British Journal of Oral and Maxillofacial Surgery, Volume 57, Issue 10Author(s): Karl Payne, Gergana Velikova, Chunxiao Song, Paul Nankivell, Hisham Mehanna
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Publication date: December 2019Source: British Journal of Oral and Maxillofacial Surgery, Volume 57, Issue 10Author(s): Carrie Newlands, Jason Thompson, Charlotte Proby, Sian Lax Williams, Catherine Harwood, Kate Fife, Jeremy Marsden, Agata Rembliak
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Publication date: December 2019Source: British Journal of Oral and Maxillofacial Surgery, Volume 57, Issue 10Author(s): James Higginson, Sadiq Mawji, Amit Dattani, Neil Barnard, Keiron McVeigh
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Publication date: December 2019Source: British Journal of Oral and Maxillofacial Surgery, Volume 57, Issue 10Author(s): Rhea Chouhan, Raveena Patel, Konstantinos Mitsimponas
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
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