Odontogenic keratocyst - the role of ptch1 and hedgehog signaling in its pathogenesis

ConclusionsOur data confirmed the high PTCH1mutation rate in both GS-related and sporadic OKCs. In PTCH1-negative cases, other genetic alterations were rare, but could also be related to Hh signaling. These results suggested that an inhibitor of the Hh pathway may be effective for the treatment of OKCs.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research