CONGENITAL-INFANTILE SPINDLE CELL AND SCLEROSING RHABDOMYOSARCOMAS: UNIQUE VARIANTS DEfiNED BY MOLECULAR FEATURES

Congenital-infantile spindle cell (SpRMS) and sclerosing (ScRMS) rhabdomyosarcomas with tumor-defining molecular features in the head and neck region will be described. These tumors may be confused with more commonly occurring spindle cell tumors (myofibroma, infantile fibrosarcoma) in infants. NCOA2 and VGLL2 rearrangements, and MyoD1 mutations are characteristically identified in SpRMS and ScRMS. NCOA2 and VGLL2 rearrangements are more common in SpRMS, while MyoD1 mutations are more common with ScRMS.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Tags: #34 Source Type: research