Verruciform xanthoma: case series of an unusual, commonly misdiagnosed lesion

Verruciform Xanthoma (VX) is a benign condition occurring primarily in the oral cavity with some lesions also found on the genital mucosa or skin. VX occurs primarily in the fifth decade of life and shows a slight male predilection. This lesion generally presents as a papillary or rough-surfaced, painless, well-demarcated lesion, ranging from white, yellow-white, to orange in color. The etiology of VX is still largely unknown and definitive diagnosis is made based on histology. This lesion is thought to correlate with localized trauma or chronic inflammatory conditions such as lichen planus, lupus, epithelial dysplasia, pemphigus vulgaris, and mucous membrane pemphigoid.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Tags: #103 Source Type: research

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Authors: Brodszky V, Tamási B, Hajdu K, Péntek M, Szegedi A, Sárdy M, Bata-Csörgő Z, Kinyó Á, Gulácsi L, Rencz F Abstract Objective: Cost-of-illness studies are widely used for healthcare decision-making; however, no such study is available in pemphigus from the societal perspective. The purpose of this analysis was to estimate annual cost-of-illness per patient with pemphigus from a societal perspective.Methods: Between 2014 and 2017, a multicenter, cross-sectional study was carried out. Consecutive pemphigus patients aged ≥18 years were recruited at all four univ...
Source: Expert Review of Pharmacoeconomics and Outcomes Research - Category: Health Management Tags: Expert Rev Pharmacoecon Outcomes Res Source Type: research
CONCLUSIONS: The influence of traditional cardiovascular risk factors on cIMT and carotid plaque is similar in RA and SLE. PMID: 31969232 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Authors: Prevete I, Espinosa G, Bellisai F, Bortoluzzi A, Conti F, Fredi M, Fonseca-Aizpuru EM, García de Viedma V, González-García A, González-León R, Iaccarino L, Iannone F, Marín-Ballvé A, Mitjavila F, Pallarés L, Piga M, Ríos-Garcés R, Suárez S, Tani C, Zanetti A, Ruiz-Irastorza G, Sebastiani GD, Gruppo di Studio SIR sul Lupus Eritematoso Sistemico di recente insorgenza-Early Lupus and Registro Español de pacientes con Lupus Eritematoso Sistémico (RELES), Autoimmune Diseases Study Group (GEAS) Abstract OBJECTIVES: To comp...
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
This study was conducted to explore the characteristics and risk factors of PE in SLE patients. METHODS: Using the Hospital Information System of Peking Union Medical College Hospital, we conducted a case-control study in SLE patients complicated with PE from January 2012 to December 2018 as the case group, and age-, sex-, and entry-time-matched SLE patients without PE at the ratio of 1:3 as the control group. We explored the risk factors of PE in SLE patients using multivariate logistic regression analyses. RESULTS: A total of 90 cases confirmed with PE from 6994 hospitalised SLE patients were identified and 257 m...
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
CONCLUSIONS: TLR3 is overexpressed in SLE skin lesions and amplifies apoptotic and inflammatory responses to UV-irradiation in antigen-presenting cells in vitro. However, TLR3 SNPs do not impact susceptibility to the development of the disease. PMID: 31969218 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Anti-microbial antibodies have been found useful for diagnosis of Crohn ’s disease (CD) and Sjogren’s syndrome (Sjo). These antibodies are also elevated in other autoimmune disease such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and multiple sclerosis (MS). The prevalence of these antibodies in the normal healthy population is unknown. We set t o survey the normal population for these anti-microbial antibodies in comparison with Crohn’s disease and others. Totally 288 blood samples from the donor units of the leukocyte-reduced red blood cells from the American Red Cross were examined...
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Diagnostics in IBD Source Type: research
This study will contribute to the understanding of the pathogenesis of splenomegaly in lupus and promote the development of an effective therapeutic strategy for SLE.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusions The clinical trials discussed here, which include several trials investigating novel therapeutic targets, demonstrate that translational research in pemphigus and pemphigoid is a fast-growing field. We thus expect that several novel treatments will be shortly available for the treatment of pemphigus and pemphigoid patients. Given the high, and thus far unmet, medical need in this field (110), this is highly encouraging and will hopefully improve the quality of life of the affected patients. In addition to the compounds and targets described here, several new targets have been recently identified in preclinical...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Feller, Liviu / Ballyram, Raoul / Khammissa, Razia AG / Altini, Mario / Lemmer, JohanPage 177 - 182Pemphigus vulgaris, mucosal pemphigoid (mucous membrane pemphigoid), lichen planus, discoid lupus erythematosus and erythema multiforme are a group of immune-mediated mucocutaneous disorders characterised clinically by the formation of blisters, erosions or ulcers. The oral mucosa is often affected, and sometimes the disease is limited to the mouth. The target antigens, autoreactive immune responses, microscopic features, treatment and prognosis vary from one disease to the other. Treatment aims to eliminate exogenous risk fa...
Source: Oral health and Preventive dentistry - Category: Dentistry Source Type: research
This article is protected by copyright. All rights reserved.) PMID: 27639053 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
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