Intratympanic Triamcinolone Acetonide as Treatment Option for Idiopathic Sudden Sensorineural Hearing Loss

Conclusion: While the exact role of intratympanic injections requires additional trials, triamcinolone resulted in similar outcomes compared to studies using dexamethasone or methylprednisolone. Due to favorable pharmacological properties, triamcinolone represents a safe and efficacious alternative for intratympanic treatment in idiopathic sensorineural hearing loss.
Source: Otology and Neurotology - Category: ENT & OMF Tags: SENSORINEURAL HEARING LOSS AND TINNITUS Source Type: research

Related Links:

In conclusion, oral administration of 1% IMU for six weeks can enhance the immune response after AI-H9N2 vaccination and reduce the pathogenicity of infection in stressed chickens. PMID: 31300109 [PubMed - in process]
Source: Comparative immunology, microbiology and infectious diseases. - Category: Allergy & Immunology Authors: Tags: Comp Immunol Microbiol Infect Dis Source Type: research
ConclusionsIpatasertib, at the monotherapy MTD of 600  mg/day and MAD of 400 mg/day in combination with abiraterone and prednisolone, was safe and tolerable in Japanese patients with solid tumors.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
ConclusionNDPH remains poorly understood but very burdensome for the individual. Multi-center randomized controlled trials are recommended to gain better understanding of NDPH and to establish evidence based treatments.
Source: The Journal of Headache and Pain - Category: Neurology Source Type: research
AbstractPurposeWe evaluated the recent incidence of surgery and the changing surgery trends for ulcerative colitis (UC) in Japan due to the increasing use of anti-tumor necrosis factor (TNF) agents.MethodsA questionnaire survey was performed to assess the number of surgeries, surgical indications, surgical timing, and immunosuppressive treatments before surgery between 2007 and 2017.ResultsA total of 3801 surgical cases were reported over 11  years. The prevalence of UC surgery decreased over the period studied. The rate of prednisolone (PSL) use did not change. The prevalence of both calcineurin inhibitors (CNIs) and...
Source: Surgery Today - Category: Surgery Source Type: research
AbstractStings from the waspParachartergus fraternus occur throughout Latin America, and edema followed by pain is the main symptom presented by victims. This often limited inflammatory event has not been characterized for this species. In this work, we identified the mechanisms and possible mediators involved in this response.P. fraternus venom (100, 200, and 400  μg/kg) was injected into the hind paws of mice, and edema was evaluated at intervals of 10 min for up to 60 min and at 120, 240, and 1440 min using a digital plethysmometer. The peak of edema was observed at 10 min with a dose of 200&...
Source: Inflammation - Category: Allergy & Immunology Source Type: research
Authors: Kim SH, Park MK PMID: 31295993 [PubMed]
Source: Clinical and Experimental Otorhinolaryngology - Category: ENT & OMF Tags: Clin Exp Otorhinolaryngol Source Type: research
Publication date: October 2019Source: Biomedicine &Pharmacotherapy, Volume 118Author(s): Yuki Azetsu, Masahiro Chatani, Yusuke Dodo, Akiko Karakawa, Nobuhiro Sakai, Takako Negishi-Koga, Masamichi TakamiAbstractGlucocorticoids (GCs) play an important role in the stress reaction and function in the development of multiple tissues in our body. When given chronically in supraphysiologic doses, GCs are associated with orthodontic tooth movement, with serious side effects and particularly adverse effects on bone metabolism. However, the effects of steroids on bone cell dynamics are incompletely understood. Therefore, in this...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Discussion Tinnitus is derived from the Latin word tinnire which means to ring but in general practice it means any perceived sound that is not generated externally. It is a common problem in adults. In children it is described as being commonly overlooked as children do not spontaneously report it. It is felt that children may consider the sound normal, or are easily distracted and therefore forget about it. Children can accurately describe the sounds they hear and use words such as buzz, ring, hum, swish, whish, blow or beep. Spontaneously reported tinnitus is ~6.5% and increases to 34% when children are specifically que...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Conclusions: The study has revealed that otitis media predominantly affects all age groups and has a serious health concern in cases affected with hearing loss and its associated co-morbidities.
Source: Egyptian Journal of Ear, Nose, Throat and Allied Sciences - Category: ENT & OMF Source Type: research
Discussion Cerumen or ear wax is produced in the outer third of the external auditory canal. It contains exfoliated squamous epithelium along with waxy substances. It is controlled by autosomal alleles and has two main phenotypes – “wet” cerumen which is dominant and common in Caucasian and African populations, and “dry” cerumen which is recessive and found more often in Asian populations. Cerumen protects the external canal and has some antibacterial and antifungal properties including against strains of Staphylococcus aureus, Pseudomonas aeroginosis, and Candida albicans. Staphylococcus aure...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
More News: Audiometry | Brain | Corticosteroid Therapy | Dexamethasone | ENT & OMF | Methylprednisolone | Neurology | Otitis | Otitis Media | Prednisolone | Statistics | Study | Tinnitus | Triamcinolone | Vertigo