Log Odds Could Better Predict Survival in Muscle-Invasive Bladder Cancer Patients Compared with pN and Lymph Node Ratio

Conclusion: LODDS has significant prognostic value for patients with MIBC. Moreover, LODDS is better at predicting prognosis for MIBC patients compared with pN and LNR.
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research

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New research suggests that a strain of the common cold may successfully treat non-muscle invasive bladder cancer, which is 'highly prevalent.'
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Cancer / Oncology Source Type: news
Publication date: Available online 11 July 2019Source: European UrologyAuthor(s): Filippo Pederzoli, Marco Bandini, Alberto Briganti, Elizabeth R. Plimack, Günter Niegisch, Evan Y. Yu, Aristotelis Bamias, Neeraj Agarwal, Srikala S. Sridhar, Cora N. Sternberg, Ulka N. Vaishampayan, Christine Théodore, Jonathan E. Rosenberg, Lauren C. Harshman, Joaquim Bellmunt, Matthew D. Galsky, Andrea Gallina, Andrea Salonia, Francesco Montorsi, Andrea NecchiAbstractThe availability of new potent systemic therapies for urothelial carcinoma may change the way we use standard chemotherapy perioperatively. In particular, identify...
Source: European Urology - Category: Urology & Nephrology Source Type: research
AbstractObjectiveTo investigate 90-day mortality rate of RC for bladder cancer in a nationwide population-based study.Design, setting, and participantsWe used mandatory hospital discharge forms of all patients submitted to RC due to bladder cancer in Spain during 2011 –2015 (n  =  12,154 in 196 hospitals). At present, a centralization policy for RC has not been issued by the health authorities.Outcome measurements and statistical analysisWe calculated in-hospital, 30-, 60- and 90-day mortality. Average annual RC volume was used as a continuous variable (log-transformed) and also grouped into deciles to ...
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
Here is a quick overview of three medical stories that are worth a mention.Medscape
Source: Medscape Hematology-Oncology Headlines - Category: Cancer & Oncology Tags: Family Medicine/Primary Care Article Source Type: news
CONCLUSIONS: We observed high rates of sampling of detrusor in the first TURBT specimen, utilization of repeat TURBT, and administration of induction and maintenance intravesical BCG for high-risk patients among a regional cohort of US Veterans with NMIBC. While not a comparative study, our findings suggest high quality NMIBC care in VA VISN 02. PMID: 31294791 [PubMed - as supplied by publisher]
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
Conditions:   Bladder Cancer;   Urothelial Carcinoma Interventions:   Drug: 18F-fluciclovine;   Device: PET/CT Sponsors:   Dana-Farber Cancer Institute;   Blue Earth Diagnostics Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractThe Cancer Genome Atlas project introduced genomic taxonomy of basal and luminal molecular subtypes in muscle invasive bladder cancer. Fewer studies have addressed the molecular classification in non-muscle invasive bladder cancer (NMIBC). Our aim is to assess the applicability of the proposed phenotypic classification for NMIBC. Three TMAs were constructed from 193 TURBT specimens of 60 bladder cancer patients treated at one of the authors ’ institutions (1998–2008). Follow-up data on recurrence, grade, or stage progression was obtained. Immunohistochemistry was performed using an automated Ventana Sys...
Source: Virchows Archiv - Category: Pathology Source Type: research
To evaluate the impact of frailty on adverse perioperative outcomes in patients treated with radical cystectomy for bladder cancer.
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
Abstract To explore the potential relationship between dairy product consumption and bladder cancer risk, we retrieved eligible studies published up to March 15, 2018, via online database search and manual review of the selected articles. Summary relative risk (RR) estimates were calculated using random-effects models based on high to low intake values. Inter-study heterogeneity was explored using stratified analyses of study design, geographic region, or whether studies adjusted for the confounders age, sex, body mass index, smoking, and education level. We extracted data from 16 studies on milk (5,193 subjects) ...
Source: Nutrition and Cancer - Category: Cancer & Oncology Authors: Tags: Nutr Cancer Source Type: research
Lynch Syndrome (LS) entails a defective DNA mismatch repair system, which is the post-replicative proofreading and editing system, ensuring our genome's integrity. LS predisposes to several cancers, most commonly colorectal and endometrial cancers. LS occurs in approximately 1 in 250 –1,000 people.LS is associated with urological malignancies with upper tract urothelial carcinoma the most common, although still clinically underestimated. Other urologic malignancies possibly associated with LS include bladder, prostate, testis, and renal cell carcinoma.
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
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