MUS81 Inhibition Increases the Sensitivity to Therapy Effect in Epithelial Ovarian Cancer via Regulating CyclinB Pathway

In this study, MUS81-downregulated cells were generated using lentivirus-mediated RNAi. Our results demonstrated that the inhibition of MUS81 expression activated the CHK1 and CyclinB signaling pathways and sensitized ovarian cancer cells to X-ray and Olaparib treatment both in vitro and in vivo. MUS81 may be a potential therapeutic target for epithelial ovarian cancer (EOC).

Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Ailing Zhong, Hui Zheng, Hongqin Zhang, Jiajun Sun, Jiabin Shen, Minjie Deng, Miaomiao Chen, Renquan Lu, Lin Guo Tags: Research Paper Source Type: research