Netrin-1 promotes cell neural invasion in gastric cancer via its receptor neogenin

In this study, we found NTN1 expression was significantly increased in 97 tumor tissues from GC patients and positively correlated with NI (p<0.05). In addition, we detected NTN1 knockdown significantly suppressed GC cells migration and invasion. Moreover, our results showed that reciprocity was observed between GC cells and neurites colonies in dorsal root ganglia (DRG)-GC cells co-culture vitro model. GC cells with NTN1 silencing could suppress their abilities to navigate along surrounding neuritis and this effect was depended on its receptor neogenin. In vivo, NTN1 inhibition also decreased GC cells sciatic nerve invasion. Taken together, our findings argue that NTN1 and its receptor neogenin might act synergistically in promoting GC cells neural invasion. Inhibiting the activity of NTN1 could be a potential strategy targeting NI in GC therapy.

Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Kai Yin, Linjun Wang, Yiwen Xia, Shengchun Dang, Xuan Zhang, Zhongyuan He, Jianghao Xu, Mengyuan Shang, Zekuan Xu Tags: Research Paper Source Type: research