Placebo Effect in the Treatment of Depression and Anxiety

The aim of this review is to evaluate the placebo effect in the treatment of anxiety and depression. Antidepressants are supposed to work by fixing a chemical imbalance, specifically, a lack of serotonin or norepinephrine in the brain. However, analyses of the published and the unpublished clinical trial data are consistent in showing that most (if not all) of the benefits of antidepressants in the treatment of depression and anxiety are due to the placebo response, and the difference in improvement between drug and placebo is not clinically meaningful and may be due to breaking blind by both patients and clinicians. Although this conclusion has been the subject of intense controversy, the current article indicates that the data from all of the published meta-analyses report the same results. This is also true of recent meta-analyis of all of the antidepressant data submitted to the FDA in the process of seeking drug approval. Also, contrary to previously published results, the new FDA analysis reveals that the placebo response has not increased over time. Other treatments (e.g., psychotherapy and physical exercise) produce the same benefits as antidepressants and do so without the side effects and health risks of the active drugs. Psychotherapy and placebo treatments also show a lower relapse rate than that reported for antidepressant medication.
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research

Related Links:

DiscussionAs psychotherapy is among the treatments of choice for most adult psychiatric disorders, a systematic review evaluating the benefits and harms of short-term compared with long-term psychotherapy is urgently needed. It is the hope that this review will be able to inform best practice in treatment and clinical research of these highly prevalent and burdensome disorders.Systematic review registrationPROSPEROCRD42019128535
Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research
   One of the most dangerous misconceptions about suicide is that asking a loved one if they are suicidal will increase the odds that they will attempt suicide.  Today Dr. Nate Ivers of Wake Forest University discusses the importance of making “the covert overt” by asking blunt, straightforward questions of those you suspect may be thinking about suicide.  What words should you use, and if the answer is yes, what should you do next?  And why are we so uncomfortable about asking these potentially lifesaving questions? Find out on this episode. SUBSCRIBE &REVIEW   Guest inform...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Depression Grief and Loss Suicide The Psych Central Show Source Type: blogs
DiscussionThe EMPOWER study is unique in its application of evidence-based psychotherapy targeting peritraumatic stress to improve patient and caregiver outcomes in the setting of critical illness. The experimental intervention will be strengthened through the input of a variety of ICU stakeholders, including behavioral health clinicians, physicians, bereaved informal caregivers, and open trial participants. Results of the RCT will be submitted for publication in a peer-reviewed journal and serve as preliminary data for a larger, multisite RCT grant application.Trial registrationClinicalTrials.gov,NCT03276559. Retrospectiv...
Source: Trials - Category: Research Source Type: clinical trials
Conclusions: Back, head and neck pains are highly prevalent among psychiatric outpatients. Multiple pain sites may reflect higher levels of psychiatric distress and greater impairment in emotional processing among psychiatric outpatients. PMID: 31271073 [PubMed - as supplied by publisher]
Source: International Journal of Psychiatry in Clinical Practice - Category: Psychiatry Tags: Int J Psychiatry Clin Pract Source Type: research
  In today’s episode, we speak with Haesue Jo, Clinical Support Lead for a large online therapy website, about their new offering for teens and adolescents.  On-line therapy is a novel idea for many — and prompts a lot of questions.  How does on-line counseling work for adolescents?  Are there a lot of differences between the experiences of teens and adults?  How are parents involved?  What are the safeguards in place?  How does payment work?  Listen in to see what online therapy for teenagers is all about.  (BetterHelp.com is a long-term sponsor of The Psych Cent...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Mental Health and Wellness Self-Help The Psych Central Show Treatment Source Type: blogs
 Jennifer Marshall is a mom, executive director, storyteller, and a woman living with bipolar disorder. In 2011, she started chronicling her challenges of living with mental illness while raising two young children.  Her story was a powerful one and connected with people all over the country, many of whom wrote to her to say that they had been inspired after reading her blog.  Jennifer knew she was onto something, and that storytelling was a powerful tool for healing.  This was the beginning of ‘This Is My Brave’ – a nonprofit with the mission of bringing stories of mental illness and ad...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Bipolar Relationships Self-Help The Psych Central Show Women's Issues Source Type: blogs
AbstractPurpose of ReviewWe reviewed research on computer-assisted cognitive-behavior therapy (CCBT) and mobile applications with the goals of assessing the effectiveness of these newer methods of delivering or augmenting treatment and making recommendations on the clinical use of computer tools in psychotherapy of depression and anxiety.Recent FindingsResearch on CCBT has found solid evidence for efficacy when the use of a therapeutic computer program is supported by a clinician or other helping professionals. Lower levels of efficacy or ineffectiveness typically have been found when computer programs are used as stand-al...
Source: Current Psychiatry Reports - Category: Psychiatry Source Type: research
This article was originally published on Undark. Read the original article.
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized mental health onetime syndication Source Type: news
In this study, combined systems pharmacology strategy and RNA-Seq technology, we uncovered psychotherapeutic effects of LJF. In brief, LJF and its active ingredient luteolin can reversed depressive/anxiety-like behavior in rats exposed to chronic mild stress (CMS), restored abnormal gene expression changes and neurotransmission in the striatum of CMS rats, these effects were mediated through triggering the activation of the HTR2A/PLCγ/ERK/CREB pathway.Graphical abstractThe concrete implementation process of systems pharmacology approach in treating psychiatric disorder with LJF (Lonicerae Japonicae Flos) is described...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
You're reading How To Keep Your Job While Dealing With Depression, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. By Suzanne Jessee, Founder and CEO, Anew Era TMS We all need to keep our jobs, right? We have financial obligations, mouths to feed, and working for a living is how we make ends meet. When depression hits, our ability to function on the job can be impacted, even putting our livelihood at risk. So, how should someone battling depression manage the mood disorder while continuing at work? It may s...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: featured health and fitness psychology self improvement Source Type: blogs
More News: Anxiety | Brain | Chemistry | Clinical Trials | Depression | Eyes | Neurology | Psychiatry | Psychotherapy | Sports Medicine