ANP-stimulated sodium secretion in the collecting duct prevents sodium retention in renal adaptation to acid load.

In conclusion, paracrine stimulation of HKA2 by ANP is responsible for the escape of the sodium retaining effect of aldosterone during metabolic acidosis.
PMID: 31188029 [PubMed - as supplied by publisher]

Source: Am J Physiol Renal P... - June 11, 2019 Category: Urology & Nephrology Authors: Cheval L, Bakouh N, Walter C, Tembely D, Morla L, Escher G, Vogt B, Crambert G, Planelles G, Doucet A Tags: Am J Physiol Renal Physiol Source Type: research