Renal Iron Accelerates the Progression of Diabetic Nephropathy in HFE (High Fe-iron) Gene Knockout Mouse Model of Iron Overload.

Renal Iron Accelerates the Progression of Diabetic Nephropathy in HFE (High Fe-iron) Gene Knockout Mouse Model of Iron Overload. Am J Physiol Renal Physiol. 2019 Jun 12;: Authors: Chaudhary K, Chilakala A, Ananth S, Mandala A, Veeranan-Karmegam R, Powell FL, Ganapathy V, Gnana-Prakasam JP Abstract Diabetic Nephropathy (DN) is the most common cause of end-stage renal disease associated with high mortality worldwide. Increase in iron levels have been reported in the diabetic rat kidneys as well as in the human urine of diabetic patients. In addition, low iron diet or iron chelators delay DN progression in diabetic patients and in animal models of diabetes. Possible maladaptive mechanisms of organ damage by tissue iron accumulation have not been well studied. We recently reported that iron induced retinal renin angiotensin system (RAS) and accelerated the progression of diabetic retinopathy. However, whether iron regulates systemic RAS is unknown. To explore if iron alters the expression of intra renal RAS and its role in the progression of DN, we used HFE (High Fe-iron) knockout mouse, a genetic model of systemic iron overload. We found that diabetes upregulated the expression of iron regulatory proteins and augmented tissue iron accumulation in the kidneys of both type-1 and type-2 diabetic mouse models. Iron accumulation in kidneys of HFE knockout mouse was associated with increase in serum and intra renal renin expression. Inducing ...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research