Concurrent chromothripsis events in a case of TP53 depleted Acute Myeloid Leukemia with myelodysplasia-related changes

Acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) mostly affects elderly adults. It is a heterogeneous disorder with poor prognosis, defined by morphological, genetic, and clinical features. Genetic abnormalities, such as -5/del(5q), -7/del(7q), and/or complex karyotypes are often detected and associated with AML-MRC [1]. The presence of ≥20% blasts in peripheral blood (PB) or bone marrow and multi-lineage dysplasia affecting ≥50% cells in two or more myeloid lineages is often thought to be straightforward criteria for AML-MRC diagnosis.

Source: Cancer Genetics and Cytogenetics - June 11, 2019 Category: Genetics & Stem Cells Authors: D. Tolomeo, A. L'Abbate, A. Lonoce, P. D'Addabbo, M.F. Miccoli, C. Lo Cunsolo, P. Iuzzolino, O. Palumbo, M. Carella, V. Racanelli, T. Mazza, E. Ottaviani, G. Martinelli, G. Macchia, C.T. Storlazzi Tags: Short Communication Source Type: research