Virtual Reality IDs Navigation Issues in Early Alzheimer Disease

WEDNESDAY, June 12, 2019 -- An entorhinal cortex-based virtual reality navigation task can differentiate patients with mild cognitive impairment at low and high risk for developing dementia, according to a study published in the June issue of...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news

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CONCLUSIONS: Amyloid-PET positivity is associated with lower MoCA scores. Clinical utility of amyloid-PET scan is likely to be suboptimal at the MoCA score cutoff for minimal cognitive impairment. PMID: 31305321 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
Authors: Kapasi A, Yu L, Stewart CC, Schneider JA, Bennett DA, Boyle PA Abstract BACKGROUND: Low health and financial literacy may be an early behavioral manifestation of cognitive impairment, dementia, and accumulating Alzheimer pathology. However, there are limited studies investigating the behavioral features associated with hyperphosphorylated transactive response DNA-binding protein-43 (TDP-43), a common age-related pathology, and even fewer studies investigating the neurobiological basis underlying low literacy in aging. OBJECTIVE: To test the hypothesis that TDP-43 pathology is associated with lower lite...
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
Protein tau may spread more rapidly in female brains than males ’, adding to range of factorsThe reason women appear to be at greater risk of developing Alzheimer ’s disease than men might be due to a number of genetic, anatomical and even social influences, researchers have suggested.Recent figures show about 65% of those with living with dementia in the UK are women, with a similar statistic seen in the US for Alzheimer ’s disease, while dementia is theleading cause of death for women in England. Alzheimer ’s disease is only one of the types of dementia, but the most common form.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Alzheimer's Science Society Health Dementia Source Type: news
In this study, we aimed to investigate correlated structural and functional brain changes in AD and BD by combining resting-state functional magnetic resonance imaging (fMRI) and diffusion MRI. A group independent component analysis was first performed on the fMRI data to extract 49 intrinsic connectivity networks (ICNs). Then we conducted a multi-set canonical correlation analysis on three features, functional network connectivity (FNC) between ICNs, fractional anisotropy (FA) and mean diffusivity (MD). Two inter-correlated components show significant group differences. The first component demonstrates distinct brain chan...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
New research gives some biological clues to why women may be more likely than men to develop Alzheimer's disease and how this most common form of dementia varies by sex
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
Regardless of how much genetic risk someone has, a good diet, adequate exercise, limiting alcohol and not smoking made dementia less likely
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news
Study indicates that wearing hearing aids could boost aspects of memory and attention in healthy older people Related items fromOnMedica Virtual reality could help spot Alzheimer ’s quicker Dementia leading cause of death in women over 80 Risk of Alzheimer ’s lower in people with gout WHO issues guidelines on dementia risk reduction LGBT community at higher risk of cognitive decline
Source: OnMedica Latest News - Category: UK Health Source Type: news
AbstractPurpose of ReviewWorldwide, approximately 50 million people have dementia (mostly Alzheimer ’s disease). Dementia results from a multicomponent pathophysiology that follows complex dynamics over many years before symptoms become apparent. Nutrition may represent a target of choice for the primary prevention of dementia; however, there is still no firm answer on how to prevent dementia ef ficiently.We provide a broad overview of recent studies leveraging system biology and life-long epidemiology to address the multidimensionality and dynamical patterns underlying dementia and improve knowledge on the link betw...
Source: Current Nutrition Reports - Category: Nutrition Source Type: research
AbstractAlzheimer ’s disease (AD), the most common cause of dementia remains of unclear etiology with current pharmacological therapies failing to halt disease progression. Several pathophysiological mechanisms have been implicated in AD pathogenesis including amyloid-β protein (Aβ) accumulation, tau hyperphospho rylation, neuroinflammation and alterations in bioactive lipid metabolism. Sphingolipids, such as sphingosine-1-phosphate (S1P) and intracellular ceramide/S1P balance are highly implicated in central nervous system physiology as well as in AD pathogenesis. FTY720/Fingolimod, a structural sphingosin...
Source: NeuroMolecular Medicine - Category: Neurology Source Type: research
Conclusions: The algorithm we developed achieved sound and high prognostic performance to predict AD conversion using easily clinically derived information that makes the algorithm easy to be translated into practice. This indicates beneficial application to improve recruitment in clinical trials and to more selectively prescribe new and newly emerging early interventions to high AD risk patients.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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