Bats Are Biggest Rabies Danger, CDC Says

A scratch or bite from a bat can be smaller than the top of a pencil eraser, but that's enough to give a person rabies, the CDC said.
Source: WebMD Health - Category: Consumer Health News Source Type: news

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Publication date: Available online 18 October 2019Source: Journal of Molecular BiologyAuthor(s): Nathan E. Jespersen, Cedric Leyrat, Francine C. Gérard, Jean-Marie Bourhis, Danielle Blondel, Marc Jamin, Elisar BarbarAbstractThe rabies and Ebola viruses recruit the highly conserved host protein LC8 for their own reproductive success. In vivo knockouts of the LC8 recognition motif within the rabies virus phosphoprotein (RavP) result in completely non-lethal viral infections. In this work, we examine the molecular role LC8 plays in viral lethality. We show that RavP and LC8 co-localize in rabies infected cells, and tha...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
Publication date: Available online 17 October 2019Source: Sensors and Actuators B: ChemicalAuthor(s): Jiaojiao Zhou, Wenjing Wang, Shuojun Li, Axiu Nie, Zhiyong Song, Mohamed F. Foda, Zhicheng Lu, Ling Zhao, Heyou HanAbstractAn innovative fluorescent and colorimetric dual-mode strategy based on Y-shaped DNA was proposed for the detection of rabies virus oligonucleotide. The cascade assembly of hairpin probes was initiated by the target, leading to the formation of Y-shaped DNA accompanied by freeing target to catalyze the next assembly process. The fluorescence recovery of the fluorophore FAM was accompanied by opening of ...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Neurons form bona fide synapses with oligodendrocyte precursor cells (OPCs), but the circuit context of these neuron to OPC synapses remains incompletely understood. Using monosynaptically-restricted rabies virus tracing of OPC afferents, we identified extensive afferent synaptic inputs to OPCs residing in secondary motor cortex, corpus callosum, and primary somatosensory cortex of adult mice. These inputs primarily arise from functionally-interconnecting cortical areas and thalamic nuclei, illustrating that OPCs have strikingly comprehensive synaptic access to brain-wide projection networks. Quantification of these inputs...
Source: eLife - Category: Biomedical Science Tags: Neuroscience Source Type: research
Condition:   Rabies (Healthy Volunteers) Interventions:   Biological: Purified vero rabies vaccine - serum free VRVg-2;   Biological: Purified inactivated rabies vaccine (Verorab);   Biological: Purified inactivated rabies vaccine (Imovax rabies) Sponsor:   Sanofi Pasteur, a Sanofi Company Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCORD, N.H. (AP) — New Hampshire health officials are requesting the public’s help in finding a man from Massachusetts to assess his risk for rabies after he came into contact with baby raccoons. Health officials say the man was in Conway at about 5 p.m. on Sept. 20 and stopped to help someone remove two baby raccoons on Route 16 between North Bald Hill Thorn Hill roads. The raccoons were brought to a wildlife rehabilitation center, where one died and was identified to have rabies. The other didn’t have rabies. Health officials said Friday the man, who drove a dark pickup truck with oversized tires and ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Offbeat Syndicated CBSN Boston New Hampshire News Rabies raccoons Source Type: news
In this study, we demonstrated that the three investigated bat isolates were pathogenic, even at low dose, when inoculated by the central route but were not/less pathogenic when administrated peripherally. The Rabisin vaccine was capable of significantly cross-protecting mice inoculated intramuscularly with EBLV-1b and EBLV-2 and intracerebrally with BBLV. The level of rabies neutralizing antibodies induced by the Rabisin was quite high against the bat lyssaviruses, but with no significant differences between immunization with 1 and 5 IU/dose. The study emphasizes that the quality of rabies-inactivated vaccines for veterin...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
This week, a method for predicting follow-up earthquakes, and the issues with deep learning systems in AI.In this episode:00:47 Which is the big quake?A new technique could allow seismologists to better predict if a larger earthquake will follow an initial tremor. Research Article: Real-time discrimination of earthquake foreshocks and aftershocks; News and Views: Predicting if the worst earthquake has passed07:46 Research HighlightsVampire bats transmitting rabies in Costa Rica, and why are some octopuses warty? Research Article: Streicker et al.; Research Article: Voight et al.10:03...
Source: Nature Podcast - Category: Science Authors: Source Type: podcasts
Nature, Published online: 08 October 2019; doi:10.1038/d41586-019-03005-5Viral genomes suggest that rabies strains carried by vampire bats travel from South America to North America, and vice versa.
Source: Nature AOP - Category: Research Source Type: research
Abstract Neuromuscular circuits (NMCs) are vital for voluntary movement, and effective models of NMCs are needed to understand the pathogenesis of, as well as to identify effective treatments for, multiple diseases, including Duchenne's muscular dystrophy and amyotrophic lateral sclerosis. Microfluidics are ideal for recapitulating the central and peripheral compartments of NMCs, but myotubes often detach before functional NMCs are formed. In addition, microfluidic systems are often limited to a single experimental unit, which significantly limits their application in disease modeling and drug discovery. Here, we ...
Source: Biomaterials - Category: Materials Science Authors: Tags: Biomaterials Source Type: research
g Sun Gao Yang Zhao Xia Rift Valley fever virus (RVFV), which causes Rift Valley fever (RVF), is a mosquito-borne zoonotic pathogen that causes serious morbidity and mortality in livestock and humans. RVF is a World Health Organization (WHO) priority disease and, together with rabies, is a major health burden in Africa. Here, we present the development and characterization of an inactivated recombinant RVFV and rabies virus (RABV) vaccine candidate (rSRV9-eGn). Immunization with rSRV9-eGn stimulated the production of RVFV-specific IgG antibodies and induced humoral and cellular immunity in mice but did n...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
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