A mouse TSH receptor A-subunit transgene expressed in thyroiditis-prone mice may provide insight into why Graves' disease only occurs in humans.

CONCLUSIONS: Multiple genetic and environmental factors contribute to the pathogenesis of Graves' disease. The present study suggests that the TSHR A-subunit structure (possibly including post-translational modification such as glycosylation) may explain, in part, why Graves' disease only develops in humans. PMID: 31184281 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research