The Combination of Stereotactic Body Radiation Therapy and Immunotherapy in Primary Liver Tumors.

The Combination of Stereotactic Body Radiation Therapy and Immunotherapy in Primary Liver Tumors. J Oncol. 2019;2019:4304817 Authors: Kreidieh M, Zeidan YH, Shamseddine A Abstract Treatment recommendations for primary liver malignancies, including hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), are complex and require a multidisciplinary approach. Despite surgical options that are potentially curative, options for nonsurgical candidates include systemic therapy, radiotherapy (RT), transarterial chemoembolization (TACE), and radiofrequency ablation (RFA). Stereotactic Body Radiation Therapy (SBRT) is now in routine use for the treatment of lung cancer, and there is growing evidence supporting its use in liver tumors. SBRT has the advantage of delivering ablative radiation doses in a limited number of fractions while minimizing the risk of radiation-induced liver disease (RILD) through highly conformal treatment plans. It should be considered in a multidisciplinary setting for the management of patients with unresectable, locally advanced primary liver malignancies and limited treatment options. Recently, the combination of immunotherapy with SBRT has been proposed to improve antitumor effects through engaging the immune system. This review aims at shedding light on the novel concept of the combination strategy of immune-radiotherapy in liver tumors by exploring the evidence surrounding the use of SBRT and immunotherapy for the treatment of HCC...
Source: Journal of Oncology - Category: Cancer & Oncology Tags: J Oncol Source Type: research

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This study examines the extent to which data linkages between Indian Health Service, tribal data, and cancer registries affect cancer incidence rates among American Indians/Alaska Natives (AI/ANs) in Michigan. The incidence of tobacco- and alcohol-associated cancers for 1995-2012 was analyzed to compare rates of the Upper Peninsula (UP) and Lower Peninsula (LP) in Michigan and among AI/ANs and non-Hispanic Whites (NHWs). Complete linkage resulted in 1,352 additional AI/AN cases; 141 cases were linked via IHS records alone, while 373 were linked via tribal records alone; 838 were linked through both IHS and tribal records. ...
Source: Journal of Health Care for the Poor and Underserved - Category: International Medicine & Public Health Authors: Tags: J Health Care Poor Underserved Source Type: research
Abstract We conducted qualitative semi-structured telephone interviews with the directors of the 10 National Institutes of Health Centers for Population Health and Health Disparities (NIH/CPHHD) to identify factors that were associated with the sustainability of 19 interventions developed to address cancer disparities and 17 interventions developed to address cardiovascular disease disparities in the United States. Interview transcripts were analyzed using the constant comparative method of analysis to identify key themes and synthesize findings. Directors at NIH/CPHHD reported that barriers to sustainability incl...
Source: Journal of Health Care for the Poor and Underserved - Category: International Medicine & Public Health Authors: Tags: J Health Care Poor Underserved Source Type: research
ConclusionsUncommon Candida species frequently exhibit high rates of non-susceptibility to antifungals. Identification of all Candida isolates at the species level from blood samples is of value for treatment.
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
Publication date: 15 December 2019Source: Journal of Molecular Structure, Volume 1198Author(s): Ali Oubella, My Youssef Ait Itto, Aziz Auhmani, Abdelkhalek Riahi, Anthony Robert, Jean-Claude Daran, Hamid Morjani, Carol A. Parish, M'hamed EsseffarAbstractNew series of chiral isoxazoles and pyrazoles with monoterpenic skeleton, have been efficiently synthesized from naturally occurring (R)-Carvone, using 1,3-dipolar cycloaddition reaction with arylonitrile oxides and diarylnitrilimines. The reaction showed high peri-, and regioselectivity. In the case of diarylnitrilimines, the reaction revealed to be highly diastereoselecti...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: Available online 20 August 2019Source: Life SciencesAuthor(s): Madhulika Singh, Kulpreet Bhui, Richa Singh, Yogeshwer Shukla
Source: Life Sciences - Category: Biology Source Type: research
Publication date: 15 November 2019Source: Carbohydrate Polymers, Volume 224Author(s): Vahid Hasantabar, Hamed Tashakkorian, Monire GolpourAbstractEfficient procedure for preparation of the novel magnetic nanobiocomposite (MNbC) was successfully established by employing click chemistry protocol. The resulted structure exhibited valuable characteristics from biological viewpoints. The prepared materials and obtained nanobiocomposite were characterized by means of nuclear magnetic resonance (NMR), fourier transform infrared (FT-IR), thermal gravimetric analysis (TGA) and differential scanning calorimetry (DSC). To assay the a...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
ConclusionDifferent from current algorithms, our technique focuses on a particular problem in the field of speech pathology detection (SPD), not yet explored in detail, proposing a way to successfully solve it. Furthermore, the results we obtained stimulate broaden studies involving speech data inconsistencies whilst providing a valid contribution.
Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research
ConclusionOur research suggests the experimental evidence for DFO and CDDP as a new effective combination therapy to enhance the efficacy of chemical therapy in ovarian cancer.
Source: Journal of Trace Elements in Medicine and Biology - Category: Biochemistry Source Type: research
New J. Chem., 2019, Advance Article DOI: 10.1039/C9NJ03088C, PaperHaiyao Yang, Yanxian Guo, Zhengfei Zhuang, Huiqing Zhong, Chaofan Hu, Zhiming Liu, Zhouyi Guo MoO3 −x is synthesizedvia a one-pot hydrothermal method, with excellent stability against aging, heat, laser exposure and chemical etching. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Publication date: Available online 16 July 2019Source: Reproductive ToxicologyAuthor(s): Barbara A. Cohn, Michele A. La Merrill, Nickilou Y. Krigbaum, Miaomiao Wang, June-Soo Park, Myrto Petreas, Gregory Yeh, Russell C. Hovey, Lauren Zimmermann, Piera M. CirilloAbstractWe tested the hypothesis that maternal perinatal serum levels of poly and perfluoroalkyl substances (PFASs) predict risk for breast cancer in daughters in a 54-year follow-up of 9300 daughters born 1959–1967 in the Child Health and Development Studies pregnancy cohort. Total cholesterol and PFASs were measured in archived maternal perinatal serum for 1...
Source: Reproductive Toxicology - Category: Toxicology Source Type: research
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