A collaborative platform for Management of Chronic Diseases via guideline-driven individualized care plans

Publication date: Available online 12 June 2019Source: Computational and Structural Biotechnology JournalAuthor(s): Gokce B. Laleci Erturkmen, Mustafa Yuksel, Bunyamin Sarigul, Theodoros N. Arvanitis, Pontus Lindman, Rong Chen, Lei Zhao, Eric Sadou, Jacques Bouaud, Lamine Traore, Alper Teoman, Sarah N. Lim Choi Keung, George Despotou, Esteban de Manuel, Dolores Verdoy, Antonio de Blas, Nicolas Gonzalez, Mikael Liljaj, Malte von Tottleben, Marie BeachAbstractOlder age is associated with an increased accumulation of multiple chronic conditions. The clinical management of patients suffering from multiple chronic conditions is very complex, disconnected and time-consuming with the traditional care settings. Integrated care is a means to address the growing demand for improved patient experience and health outcomes of multimorbid and long-term care patients. Care planning is a prevalent approach of integrated care, where the aim is to deliver more personalized and targeted care creating shared care plans by clearly articulating the role of each provider and patient in the care process. In this paper, we present a method and corresponding implementation of a semi-automatic care plan management tool, integrated with clinical decision support services which can seamlessly access and assess the electronic health records (EHRs) of the patient in comparison with evidence based clinical guidelines to suggest personalized recommendations for goals and interventions to be added to the indi...
Source: Computational and Structural Biotechnology Journal - Category: Biotechnology Source Type: research

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Authors: Handra-Luca A PMID: 31416300 [PubMed - as supplied by publisher]
Source: Journal of Neurogastroenterology and Motility - Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research
Publication date: Available online 17 August 2019Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Komal Agrawal, Pradeep VermaAbstractThe dye industries have exploded tremendously since industrialization, as the consumption increases pressure upon the industries to meet the demands. Thereby leading to release of toxic chemicals and effluents in the surrounding environment. Alizarin Cyanine Green (ACG) a toxic dye has its utility in various industries and after utilization remaining dye and intermediates are released as effluent. The treatment of ACG using photocatalytic mechanism has been studied however studi...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01275C, CommunicationSengodagounder Muthusamy, Ammasi Prabu, E Suresh An atom-economical synthesis of spiro-indolofurobenzopyrans has been developed from diazoamides and O-propargyl salicylaldehydes in the presence of copper(I) thiophene-2-carboxylate in a diastereoselective manner. This methodology involves the carbonyl ylide intermediates... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
CONCLUSION: ATV inhibited ROS generation and activated IL-1 β/IL-6 secretion in PBMNC of diabetes patients. Its effect was not affected by the hyperglymemia. PMID: 31416412 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
Conclusion Dexamethasone appears to be a promising agent in reduction of post-operative sequelae in third molar surgery. As a potent anti-inflammatory agent it has an effective role in pain, trismus and edema reduction distinguish from the routes of administration, dosage and timing, pre or post-operative prescription. PMID: 31416411 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
Methods to Quantify the NF-κB Pathway During Senescence. Methods Mol Biol. 2019;1896:231-250 Authors: Zhang L, Zhao J, Gurkar A, Niedernhofer LJ, Robbins PD Abstract Nuclear factor κB (NF-κB) is a family of transcription factors important for regulating innate and adaptive immunity, cellular proliferation, apoptosis and senescence. The NF-κB family is comprised of five subunits, RelA/p65, RelB, C-Rel, p50 (p105/NF-κB1), and p52 (p100/NF-κB2). NF-κB activity goes up with age in multiple tissues. The two subunits RelA/p65 and p50 have been implicated in senescen...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
Phys. Chem. Chem. Phys., 2019, Accepted Manuscript DOI: 10.1039/C9CP03786A, PaperNikolay V. Tkachenko, Dmitriy Steglenko, Nikita Fedik, Natalia M. Boldyreva, Ruslan M. Minyaev, Vladimir I. Minkin, Alexander Boldyrev Among the diversity of new materials, two-dimensional crystal structures attract significant attention of broad scientific community due to its promising applications in nanoscience. In this work we predicted a novel... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Phys. Chem. Chem. Phys. latest articles - Category: Chemistry Authors: Source Type: research
In this study, site-specific release retardant mini-matrix tablets (SSRRMT) were developed and functionally coated with pH-responsive materials to achieve a site-specific delivery of DT at the duodenojejunal (DSRRMT) and ileocecal (ISRRMT) regions. Stomach-specific coated mini-tablets (SSCMT) were manufactured for immediate release of about 16% of the daily dose of DT in the stomach. The SSCMT, DSRRMT and ISRRMT were combined into a solid dosage form (C-SSRRMT tablets or capsules) to achieve the required linear release profile for once daily administration of DT. The SSRRMT and C-SSRRMT formulations were evaluated for the ...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
Halogenated boroxine dipotassium trioxohydroxytetrafluorotriborate K2[B3O3F4OH] inhibits emerging multidrug-resistant and β-lactamase-producing opportunistic pathogens. Drug Dev Ind Pharm. 2019 Aug 16;:1-21 Authors: Maravić A, Rončević T, Krce L, Ilić N, Galić B, Čikeš Čulić V, Carev I Abstract Halogenated boroxine dipotassium trioxohydroxytetrafluorotriborate, K2[B3O3F4OH] (boroxine) was previously shown to be very effective in inhibition of several carcinoma cell lines, including the skin cancer. Here, we investigated its antimicrobial potential by targeting the multidrug-resistan...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
CONCLUSION: The study introduced rapidly dissolving buccal film for enhanced dissolution and bioavailability of naftopidil. PMID: 31418592 [PubMed - as supplied by publisher]
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
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